产品封面图

CARD12 Rabbit pAb, Biotin conj

ugated(bs-20016R-Bio)-100ul
收藏
  • ￥2980
  • Bioss已认证
  • bs-20016R-Bio
  • 2025年10月15日
  • 产品信息以Bioss网站为准
avatar
北京博奥森生物技术有限公司
品牌商
10 年钻石会员

  • 企业认证

    点击 QQ 联系

    • 相关产品推荐更多 >

    万千商家帮你免费找货

    0 人在求购买到急需产品
    • 详细信息
    • 文献和实验
    • 技术资料
    • 应用范围：

      产品信息以Bioss网站为准

    • 规格：

      100ul

    产品编号bs-20016R-Bio
    英文名称CARD12 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的凋亡加强结构域蛋白12抗体
    英文别名LRR; CARD 12; CARD; CARD LRR and NACHT containing protein 1; CARD LRR and NACHT containing protein; CARD12; Caspase recruitment domain containing protein 12; Caspase recruitment domain-containing protein 12; CLAN 1; CLAN A; CLAN; CLAN B; CLAN C; CLAN D; Clan protein; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR 2.1; CLR2.1; ICE protease activating factor; Ice protease-activating factor; Ipaf; NLR family CARD domain containing 4; NLR family CARD domain-containing protein 4; NLRC 4; NLRC4; NLRC4_HUMAN; and NACHT-containing protein.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human CARD12
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cell Death > Apoptosis > Metabolism

    Cell Biology > Apoptosis > Intracellular > Caspases etc > CARD Family

    Epigenetics and Nuclear Signaling > Cell cycle > Apoptosis > Nuclear

    Immunology > Innate Immunity > Macrophage / Inflamm.

    Metabolism > Pathways and Processes > Metabolism processes > Apoptosis

    亚基Component of the NLRC4 inflammasome. Homooligomer. Interacts with ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction. Interacts with EIF2AK2/PKR.
    亚细胞定位Cytoplasm. Cytoplasm, cytosol. Note=Cytoplasmic filaments.
    组织特异性Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
    翻译后修饰Phosphorylated at Ser-533 following infection of macrophages with S.typhimurium (Salmonella). Phosphorylation is essential for NLRC4 inflammasome function to promote caspase-1 activation and pyroptosis. PRKCD phosphorylates Ser-533 in vitro.
    相似性Contains 1 CARD domain.
    Contains 14 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
    功能Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene. NLRC4 is best associated with triggering formation of the inflammasome. Unlike NLRP3, certain inflammasome-dependent functions of NLRC4 may be carried out independently of the inflammasome scaffold ASC. Human Ced4 homologs include APAF1, NOD1 (CARD4), and NOD2 (CARD15). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。

    图标文献和实验
    相关实验
    图标技术资料

    暂无技术资料 索取技术资料

    同类产品报价

    产品名称
    产品价格
    公司名称
    报价日期
    CARD12 Rabbit pAb
    ￥600
    杭州戴格生物技术有限公司
    2025年12月19日询价
    CARD12 Polyclonal Antibody Biotin Conjugated[C91421Bio]
    询价
    南京赛戈巍生物科技有限公司
    2025年09月22日询价
    CARD12 抗体-CARD12 Antibody
    ￥22
    艾美捷科技有限公司
    2025年07月08日询价
    SARS-CoV-2 N Rabbit pAb(bs-41417R)-100ug
    ￥2500
    北京博奥森生物技术有限公司
    2025年10月16日询价
    CARD12 antibody
    ￥5000
    深圳欣博盛生物科技有限公司
    2025年07月13日询价
    CARD12 Rabbit pAb, Biotin conjugated(bs-20016R-Bio)-100ul
    ￥2980