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ERCC1 Mouse mAb, AP conjugated

(bsm-33084M-AP)-100ul
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  • ￥2980
  • Bioss已认证
  • bsm-33084M-AP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 规格：

      100ul

    产品编号bsm-33084M-AP
    英文名称ERCC1 Mouse mAb, AP conjugated
    中文名称AP标记的DNA切除修复蛋白1单克隆抗体
    英文别名Excision Repair Cross Complementing 1; DNA excision repair protein ERCC-1; COFS4; UV20; DNA excision repair protein ERCC1; ERCC 1; Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1; Excision repair protein; UV 20; UV20; DNA excision repair protein ERCC-1.
    产品应用WB=1:500-1000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Mouse
    免疫原Recombinant human ERCC1 protein
    亚型IgG
    纯化方法affinity purified by Protein G
    克隆类型Monoclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Tumor biomarkers

    Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > Nucl. Excision Repair

    亚基Heterodimer composed of ERCC1 and XPF/ERRC4.
    亚细胞定位Nucleus.
    相似性Belongs to the ERCC1/RAD10/SWI10 family.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

     

    应用推荐稀释比例
    {WB}{1:500-1000}

     

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