- ￥2980
- Bioss
- bs-3338R-BF750
- 2025年09月30日
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100ul
| 产品编号 | bs-3338R-BF750 |
| 英文名称 | phospho-PLCG 2 (Tyr1217) Rabbit pAb, BF750 conjugated |
| 中文名称 | BF750标记的磷酸化磷酯酶Cγ2抗体 |
| 英文别名 | PLCG 2(phospho Y1217); p-PLCG 2(phospho Y1217); PLCG2(phospho Y1217); phospho-PLC γ2(Tyr1217); phospho-PLC gamma 2/PLCG2(Tyr1217); PLC 2; PLC gamma 2; PLC IV; PLCG2; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2; EC 3.1.4.11; phosphoinositide phospholipase C; phospholipase C gamma 2; phospholipase C, gamma 2(phosphatidylinositol specific); PLCG2_HUMAN. |
| 产品应用 | Flow-Cyt=1μg /Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human PLC gamma 2 around the phosphorylation site of Tyr1217 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Hydrolysis Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Hydrolysis Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Signaling Pathway > Lipid Signaling > PLC |
| 亚基 | Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) . |
| 翻译后修饰 | Phosphorylated on tyrosine residues by CSF1R. Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity. |
| 相似性 | Contains 1 C2 domain. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain. Contains 2 SH2 domains. Contains 1 SH3 domain. |
| 功能 | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide specific phospholipase C enzymes, C beta is regulated by heterotrimeric G protein coupled receptors, while the closely related C gamma 1 and C gamma 2 enzymes are controlled by receptor tyrosine kinases. The C gamma 1 and C gamma 2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg /Test} |
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phospho-PLCG 2 (Tyr1217) Rabbit pAb, BF750 conjugated(bs-3338R-BF750)-100ul
￥2980
