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- bsm-30099M-PE-Cy7
- 2025年09月30日
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- 规格：
25T/50T/100T
| 规格： | 25T | 产品价格： | ￥1380.0 |
|---|---|---|---|
| 规格： | 50T | 产品价格： | ￥2280.0 |
| 规格： | 100T | 产品价格： | ￥3880.0 |
| 产品编号 | bsm-30099M-PE-Cy7 |
| 英文名称 | human CD22 Mouse mAb, PE-Cy7 conjugated |
| 中文名称 | PE-Cy7标记的小鼠抗人CD22单克隆抗体 |
| 英文别名 | B-cell receptor CD22; B cell receptor CD22 precursor; B lymphocyte cell adhesion molecule; BL CAM; BL-CAM; BLCAM; CD 22; CD22 antigen; CD22 molecule; CD22 protein; Leu14; Lyb8; MGC130020; Sialic acid binding immunoglobulin like lectin 2; SIGLEC 2; SIGLEC2; SIGLEC-2; FLJ22814; MGC130020; CD22_HUMAN; B-lymphocyte cell adhesion molecule; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14. |
| 产品应用 | Flow-Cyt=10ul/Test Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | KLH conjugated synthetic peptide derived from human CD22 |
| 亚型 | Mouse IgG1 |
| 纯化方法 | affinity purified by Protein G |
| 克隆类型 | Monoclonal |
| 储存液 | 0.01M PBS (pH7.4), 0.5% BSA, 0.02% Proclin300. |
| 研究领域 | Cancer > Tumor biomarkers > Tumor antigens Cancer > Tumor immunology > Tumor-associated antigens Immunology > Adaptive Immunity > B Cells > CD Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage |
| 亚基 | Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation. May form a complex with INPP5D/SHIP, GRB2 and SHC1. |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. |
| 组织特异性 | B-lymphocytes. |
| 翻译后修饰 | Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. |
| 相似性 | Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family._x000D_
Contains 6 Ig-like C2-type (immunoglobulin-like) domains._x000D_ Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
| 保存条件 | Store at 2-8℃. Protect from light. Avoid freezing. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome. [provided by Alliance of Genome Resources, Nov 2021] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {10ul/Test} |
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human CD22 Mouse mAb, PE-Cy7 conjugated(bsm-30099M-PE-Cy7)-25T/50T/100T
￥1380 - 3880
