Clusterin Rabbit pAb, HRP conjugated(bs-1354R-HRP)-100ul

Clusterin Rabbit pAb, HRP conj

ugated(bs-1354R-HRP)-100ul
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  • ￥2980
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  • bs-1354R-HRP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 规格：

      100ul

    产品编号bs-1354R-HRP
    英文名称Clusterin Rabbit pAb, HRP conjugated
    中文名称HRP标记的载脂蛋白J（APOJ）抗体
    英文别名CLUS_HUMAN; Aging-associated gene 4 protein; Apolipoprotein J(Apo-J); Complement cytolysis inhibitor(CLI); Complement-associated protein SP-40, 40; Ku70-binding protein 1; NA1/NA2; Sulfated glycoprotein 2(SGP-2); Testosterone-repressed prostate message 2(TRPM-2); APOJ; CLI; KUB1; AAG4; CLU2; SGP2; SP-40; TRPM2; CLU;
    产品应用IHC-P=1:100-500, IHC-F=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human CLU
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Tumor biomarkers

    Cardiovascular > Lipids / Lipoproteins > Lipoproteins/Apolipoproteins

    Cardiovascular > Lipids / Lipoproteins > Lipoproteins/Apolipoproteins > Apolipoproteins

    Immunology > Innate Immunity > Complement > Classical Pathway

    Metabolism > Types of disease > Cancer

    Signal Transduction > Metabolism > Lipid metabolism

    亚细胞定位Nucleus. Cytoplasm. Mitochondrion membrane. Cytoplasm, cytosol. Microsome. Endoplasmic reticulum. Cytoplasmic vesicle, secretory vesicle, chromaffin granule. Isoforms lacking the N-terminal signal sequence have been shown to be cytoplasmic and/or nuclear. Secreted isoforms can retrotranslocate from the secretory compartments to the cytosol upon cellular stress. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins. Detected at the mitochondrion membrane upon induction of apoptosis and Secreted. Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress.
    组织特异性Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.
    翻译后修饰Isoform 1 is proteolytically cleaved on its way through the secretory system, probably within the Golgi lumen._x000D_ Polyubiquitinated, leading to proteasomal degradation._x000D_
    Heavily N-glycosylated. About 30% of the protein mass is comprised of complex N-linked carbohydrate.
    相似性Belongs to the clusterin family.
    功能Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料

    The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}

     

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