- ￥2980
- Bioss
- bs-10362R-BF555
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
RNF157 Rabbit pAb, HRP conjugated(bs-9226R-HRP)-100ul
￥2980
SLC25A38 Rabbit pAb, BF750 conjugated(bs-19815R-BF750)-100ul
￥2980phospho-MDM2 (Ser188 + Ser186) Rabbit pAb, BF488 conjugated(bs-18747R-BF488)-100ul
￥2980
GLP-1(1G9) Mouse mAb, Cy3 conjugated(bsm-0933M-Cy3)-100ul
￥2980
WASF2 Rabbit pAb, PE-Cy5.5 conjugated(bs-6243R-PE-Cy5.5)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-10362R-BF555 |
| 英文名称 | TPOR Rabbit pAb, BF555 conjugated |
| 中文名称 | BF555标记的血小板生成素受体抗体 |
| 英文别名 | C MPL; C-MPL; CMPL; CD110; CD 110; MPL; MPLV; Myeloproliferative leukemia protein; Myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; THCYT2; Thrombopoietin receptor; TPO R; TPO-R; TPOR; TPOR_HUMAN. |
| 产品应用 | Flow-Cyt=3μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TPOR |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Cell Type Markers > CD > Platelets Stem Cells > Hematopoietic Progenitors > Myeloid > Thrombocytic Lineage |
| 亚基 | Interacts with ATXN2L |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed. |
| 翻译后修饰 | Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination. |
| 相似性 | Belongs to the type I cytokine receptor family. Type 1 subfamily. _x000D_ Contains 2 fibronectin type-III domains. |
| 功能 | Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {3μg/Test} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
TPOR Rabbit pAb, BF555 conjugated(bs-10362R-BF555)-100ul
￥2980
