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| 产品编号 | bs-2616R-AP |
| 英文名称 | IL18R Beta Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的白细胞介素-18受体β链抗体 |
| 英文别名 | IL-18R beta; Interleukin-18 receptor beta; Accessory protein like; IL18R beta; AcPL; IL 18RacP; IL 1R accessor protein like; IL 1R7; IL 1RacPL; IL18Rbeta; Interleukin 18 receptor accessory protein; IL18RAP; Interleukin-18 receptor accessory protein-like; IL-18R-beta; IL-18Rbeta; Accessory protein-like; AcPL; Interleukin-1 receptor 7; IL-1R-7; IL-1R7; CD218 antigen-like family member B; CD218b; I18RA_HUMAN. |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human IL-18R beta |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor immunology > Cytokines > Interleukins Immunology > Innate Immunity > Cytokines > Interleukins Immunology > Innate Immunity > Macrophage / Inflamm. Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Cytokines and cytokine receptors ELISA kits Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Interleukin ELISA kits |
| 亚基 | Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. |
| 相似性 | Belongs to the interleukin-1 receptor family._x000D_
Contains 2 Ig-like C2-type (immunoglobulin-like) domains._x000D_ Contains 1 TIR domain. |
| 功能 | Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | IL18R Beta is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and IL18R Beta is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ELISA} | {1:5000-10000} |
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文献和实验tumor necrosis factor–{alpha} (TNF-{alpha}), interferon-beta (IFN-beta), and IFN-{gamma} (1). The authors observed that of ~200 miRNAs examined, only miR-155 increased in amount in response to both TLR ligands and IFN-beta. miR-155 accumulated
1 月内连登 4 顶刊，这个炙手可热的明星蛋白 GDF15 到底什么来路？
作用2019 年 12 月 9 号，来自加拿大麦克马斯特大学 Gregory R. Steinberg 课题组首先发力，在 Nature Metabolism 发表了题为《Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss》6 的研究。图片来源：Nature Metabolism该研究在对接受神药二甲双胍治疗的小鼠进行转录组学分析后，发现了 GDF
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