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- bs-22254R-HRP
- 2025年09月30日
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100ul
| 产品编号 | bs-22254R-HRP |
| 英文名称 | PAX6 Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的转录因子Pax6抗体 |
| 英文别名 | AN 2; AN antibody; AN2; Aniridia type II protein; D11S812E; MGC17209; MGDA; Oculorhombin; Paired box 6; Paired box gene 6(aniridia keratitis); Paired Box Gene 6; Paired box homeotic gene 6; Paired box protein Pax-6; Paired box protein Pax6; PAX 6; PAX6; PAX6_HUMAN; Sey; WAGR. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human PAX6 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Developmental Biology > Lineage specification > Ectoderm Developmental Biology > Lineage specification > Endoderm Developmental Biology > Organogenesis > Gut development > Pancreas development Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families > PAX Neuroscience > Cell Type Marker > Neural Stem Cell marker Neuroscience > Neurology process > Neural Signal Transduction Stem Cells > Lineage Markers > Ectoderm Stem Cells > Lineage Markers > Endoderm |
| 亚基 | Interacts with MAF and MAFB (By similarity). Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form. |
| 翻译后修饰 | Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. |
| 相似性 | Belongs to the paired homeobox family._x000D_
Contains 1 homeobox DNA-binding domain._x000D_ Contains 1 paired domain. |
| 功能 | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. The PAX2 gene is expressed in primitive cells of the kidney, ureter, eye, ear, and central nervous system. More specifically, in human embryo sections, PAX2 is expressed in the optic vesicle and later in the retina, in the otic vesicle and later in the semicircular canals of the inner ear, and in mesonephros, metanephros, adrenals, spinal cord, and hindbrain. PAX2 mutations can be responsible for renal hypoplasia, either isolated or associated with various ophthalmologic manifestations ranging from retinal coloboma to microphthalmia. The gene which encodes Pax-2 maps to human chromosome 10q24.3-q25.1. Lesions in the PAX6 gene accounts for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. PAX6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The gene which encodes Pax-6 maps to human chromosome 11p13. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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PAX6 Rabbit pAb, HRP conjugated(bs-22254R-HRP)-100ul
￥2980
