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- bs-22470R-HRP
- 2025年09月30日
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100ul
| 产品编号 | bs-22470R-HRP |
| 英文名称 | Haspin Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的丝氨酸/苏氨酸蛋白激酶蛋白抗体 |
| 英文别名 | germ cell associated 2; Germ cell-specific gene 2 protein; GSG2; H-Haspin; Haploid germ cell-specific nuclear protein kinase; HASP_HUMAN; Serine/threonine-protein kinase Haspin. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse Haspin |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Phosphorylation |
| 亚细胞定位 | Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis. |
| 组织特异性 | Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines. |
| 翻译后修饰 | Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis. |
| 相似性 | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. Contains 1 protein kinase domain. |
| 功能 | Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Haspins is a protein family containing a distinctive C-terminal kinase domain and a divergent N-terminus. Haspin homologues occur within a diverse group of eukaryotes, including animals, plants and fungi, which suggests an early evolutionary origin. Haspin, a nuclear protein strongly expressed in male germ cells, is responsible for the phosphorylation of histone H3 at Thr-3. Depletion of Haspin RNA prevents normal alignment of chromosomes at metaphase, suggesting a crucial role for haspin during chromosome segregation. Expression of haspin also occurs in adult thymus and bone marrow, with weaker expression in adult prostate, intestine, lung, spleen, and lymph node. The gene encoding human haspin maps to chromosome 17p13. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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Haspin Rabbit pAb, HRP conjugated(bs-22470R-HRP)-100ul
￥2980
