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- Bioss
- bs-12387R-BF680
- 2025年09月30日
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100ul
| 产品编号 | bs-12387R-BF680 |
| 英文名称 | KIF13B Rabbit pAb, BF680 conjugated |
| 中文名称 | BF680标记的驱动蛋白家族蛋白13B抗体 |
| 英文别名 | GAKIN; Guanylate kinase associated kinesin; KI13B_HUMAN; KIAA0639; KIF 13B; KIF13B; Kinesin 13B; Kinesin family member 13B; Kinesin like protein GAKIN; Kinesin like protein KIF13B; Kinesin-like protein GAKIN; Kinesin-like protein KIF13B; OTTHUMP00000225649. |
| 产品应用 | IF=1:200-800 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human KIF13B |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Motor Proteins > Kinesin-like |
| 亚基 | Binds to DLG1 and DLG4. Interacts (when phosphorylated at Ser-1381 and Ser-1410) with 14-3-3. |
| 亚细胞定位 | Cytoplasm; cytoskeleton. |
| 组织特异性 | Ubiquitous. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the kinesin-like protein family. _x000D_ Contains 1 CAP-Gly domain. _x000D_ Contains 1 FHA domain. _x000D_ Contains 1 kinesin-motor domain. |
| 功能 | May be involved in reorganization of the cortical cytoskeleton. May be functionally important for the intracellular trafficking of MAGUKs and associated protein complexes. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | KIF13B is also known as Kinesin-like protein GAKIN or GAKIN and is a 1,826 amino acid protein that is widely expressed in tissues, with highest expression in brain and kidney. KIF13B is localized to the cytoplasm, as well as to the cytoskeleton, and is thought to be a microtubule-dependent motor protein which is able to bind to a variety of proteins in order to traffic them to various locations throughout the cell. KIF13B belongs to the kinesin-like protein family and possesses three domains typical of the kinesin-like protein family, namely an N-terminal motor domain with an ATP-binding motif, an FHA domain which is known to bind diverse cargos and a large stalk domain involved in protein-protein binding. Additionally, KIF13B has a microtubule-interacting sequence which is known as the CAP-Gly domain at its C-terminus. The CAP-Gly domain is highly conserved domain among eukaryotes, and in humans, defects in the CAP-Gly domain are implicated in many diseases affecting the trafficking of vesicles, neuromuscular junctions and lysosome proliferation. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:200-800} |
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KIF13B Rabbit pAb, BF680 conjugated(bs-12387R-BF680)-100ul
￥2980
