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- Bioss
- bs-10288R-HRP
- 2025年09月30日
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100ul
| 产品编号 | bs-10288R-HRP |
| 英文名称 | C5R1 Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的补体成分5受体1抗体 |
| 英文别名 | ANAPHYLATOXIN RECEPTOR; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin receptor; C5A; C5a ligand; C5a-R; C5aR; C5AR_HUMAN; c5ar1; CD88; CD88 antigen; Complement component 5 receptor 1; Complement component 5 receptor 1; Complement component 5 receptor 2; Complement component 5a receptor 1. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human C5R1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Innate Immunity > Complement > MAC Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Vitamins / minerals Signal Transduction > Metabolism > Vitamins / Minerals Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR |
| 亚基 | Interacts with ARRB1 and ARRB2. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 翻译后修饰 | Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-10288P is one synthetic peptide derived from human C5R1. CD88, also known as C5a receptor (C5aR), is a G protein-coupled integral membrane protein. CD88, which is expressed on neutrophils, monocytes, macrophages, hepatocytes and mast cells, as well as on various epithelial and endothelial cells, serves as a receptor for the inflammatory peptide C5a. Research studies suggest a role for CD88 in the inflammatory response. The binding of C5a to CD88 has been shown to elicit increased production of acute phase proteins in liver. In brain, an increased production of CD88 has been shown to be associated with inflammation. Research also indicates a role for C5a/C5aR in the pathogenesis of rheumatoid arthritis, as well as a heightened responsiveness of human bronchial epithelial cells (HBECs) to C5a upon exposure of these cells to cigarette smoke and other environmental irritants. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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