MDR1/P Glycoprotein Rabbit pAb, Cy7 conjugated(bs-1468R-Cy7)-100ul

MDR1/P Glycoprotein Rabbit pAb

, Cy7 conjugated(bs-1468R-Cy7)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-1468R-Cy7
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格：

      100ul

    产品编号bs-1468R-Cy7
    英文名称MDR1/P Glycoprotein Rabbit pAb, Cy7 conjugated
    中文名称Cy7标记的多药耐药蛋白/P-糖蛋白(C端)抗体
    英文别名ABC20; ABCB1; ATP binding cassette, sub family B(MDR/TAP), member 1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; MDR1; MDR1_HUMAN; Multidrug resistance 1; Multidrug resistance protein 1; P glycoprotein 1; P gp; P-glycoprotein 1; PGY1.
    中文别名p-gp; P糖蛋白
    产品应用Flow-Cyt=1µg/Test, ICC/IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human MDR1
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Drug resistance > P glycoproteins

    Signal Transduction > Metabolism > Plasma Membrane > ATPases

    Signal Transduction > Metabolism > Plasma Membrane > Channels

    Stem Cells > Hematopoietic Progenitors > Side Population

    Stem Cells > Hematopoietic Progenitors > Surface Molecules

    亚基Interacts with PSMB5.
    亚细胞定位Cell membrane; Multi-pass membrane protein.
    组织特异性Expressed in liver, kidney, small intestine and brain.
    相似性Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    _x000D_ Contains 2 ABC transmembrane type-1 domains.
    _x000D_ Contains 2 ABC transporter domains.
    功能Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells._x000D_ Subunit : Interacts with PSMB5.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料bs-1468P is one synthetic peptide derived from human MDR1. P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

     

    应用推荐稀释比例
    {Flow-Cyt}{1µg/Test}
    {ICC/IF}{1:100-500}

     

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