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- Bioss
- bs-23805R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-23805R-Bio |
| 英文名称 | ATR Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的丝氨酸/苏氨酸蛋白激酶ATR抗体 |
| 英文别名 | ACTR; AIB1; amplified in breast cancer 1; Ataxia Telangiecasia and Rad3 Related; Ataxia telangiectasia and Rad3 related; Ataxia telangiectasia and Rad3-related protein; ATR; ATR_HUMAN; CAGH16; CBP interacting protein; CTG26; FCTCS; FRAP Related Protein 1; FRAP-related protein 1; FRP 1; FRP1; Human JTV 1; MEC1; MEC1 mitosis entry checkpoint 1 homolog; nuclear receptor coactivator 3; pCIP; protein kinase ATR; RAC3; Rad3 related protein; receptor associated coactivator 3; SCKL; SCKL1; Seckel syndrome; Serine/threonine protein kinase ATR; Serine/threonine-protein kinase ATR; steroid receptor coactivator protein 3; thyroid hormone receptor activator molecule 1; TRAM1. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ATR |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Angiogenic Factors Cardiovascular > Angiogenesis > Endothelial Cell Markers Microbiology > Protein > Human Protein > Defensin Tags & Cell Markers > Cell Type Markers > Epi / Endo-thelial Tags & Cell Markers > Cell Type Markers > Tumor Associated |
| 亚基 | Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interaction is enhanced by estradiol. Found in a complex containing NCOA3, AR and MAK. Interacts with DDX5. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus. |
| 组织特异性 | Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary. |
| 翻译后修饰 | Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function. Methylated by CARM1 (By similarity). Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function. |
| 相似性 | Belongs to the PI3/PI4-kinase family. ATM subfamily._x000D_
Contains 1 FAT domain._x000D_ Contains 1 FATC domain._x000D_ Contains 2 HEAT repeats._x000D_ Contains 1 PI3K/PI4K domain. |
| 功能 | Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR is a member of the DNA-PK kinases closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes. Several known components of the NuRD complex including histone deacetylase 1 (HDAC1), HDAC2, and CHD4 |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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ATR Rabbit pAb, Biotin conjugated(bs-23805R-Bio)-100ul
￥2980
