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- Bioss
- bs-4248R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-4248R-Bio |
| 英文名称 | ORP150 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的氧气调节蛋白150抗体 |
| 英文别名 | 150 kDa oxygen regulated protein; 150 kDa oxygen-regulated protein; 170 kDa glucose regulated protein; 170 kDa glucose-regulated protein; DKFZp686N08236; FLJ94899; FLJ97572; glucose regulated protein 170; Grp 170; GRP-170; Grp170; HSP 12A; HSP12A; Hyou1; HYOU1_HUMAN; Hypoxia up regulated 1; hypoxia up-regulated 1 precursor; Hypoxia up-regulated protein 1; Hypoxia upregulated 1; Orp 150; ORP-150; Orp150; oxygen regulated protein(150kD). |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ORP150 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Cancer > Invasion/microenvironment > Hypoxia > Hypoxia-related proteins Cardiovascular > Hypoxia > Associated Proteins Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > Hypoxia regulated Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Neuroscience > Neurology process > Neurodegenerative disease Signal Transduction > Protein Trafficking > Chaperones > Other Chaperones Signal Transduction > Protein Trafficking > ER Proteins |
| 亚基 | Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. |
| 亚细胞定位 | Endoplasmic reticulum lumen. |
| 组织特异性 | Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. |
| 相似性 | Belongs to the heat shock protein 70 family. |
| 功能 | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ORP150 (150KDa Oxygen-regulated Protein) is a member of the heat shock protein/stress protein family and has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. This protein has also been described as a molecular chaperone, induced by various environmental and physiological stimuli, and participates in protein folding in the endoplasmic reticulum. Furthermore, ORP150 is up-regulated in tumors and, in breast tumors, may be associated with tumor invasiveness. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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