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MAFG Rabbit pAb, AP conjugated

(bs-18615R-AP)-100ul
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  • ￥2980
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  • bs-18615R-AP
  • 2025年09月30日
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      100ul

    产品编号bs-18615R-AP
    英文名称MAFG Rabbit pAb, AP conjugated
    中文名称AP标记的转录因子MAFG抗体
    英文别名AA545192; Basic leucine zipper transcription factor MafG; C630022N07Rik; hMAF; MAFG; MAFG v maf musculoaponeurotic fibrosarcoma oncogene homolog G(avian); MAFG_HUMAN; MGC13090; MGC20149; RP23 84C12.9; Transcription factor MafG; V maf musculoaponeurotic fibrosarcoma oncogene homolog G; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human MAFG
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Other Antibodies > Oxidative Stress

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Leucine Zipper

    Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription

    Epigenetics and Nuclear Signaling > Transcription > Transcription Factors

    Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress

    亚细胞定位Nucleus.
    组织特异性Highly expressed in skeletal muscle. Also expressed in heart and brain.
    翻译后修饰Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no effect on binding NFE2.
    _x000D_ Sumoylation at Lys-14 is required for active transcriptional repression.
    相似性Belongs to the bZIP family. Maf subfamily.
    _x000D_ Contains 1 bZIP domain.
    功能Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+).
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

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    图标文献和实验
    相关实验

    • Western 杂交

      SDS-PA gels, and subsequent detection of proteins using rabbit antisera and alkaline phosphatase-conjugated goat-anti-rabbit IgG, detected using bromo-chloro-indolyl phosphate (BCIP) and Nitro-blue tetrazolium (NBT) salts.    ・        

    • Developing Genetically Engineered Mouse Models to Study Tumor Suppression

      Literature Cited    Armstrong, J.F., Kaufman, M.H., Harrison, D.J., and Clarke, A.R. 1995. High‐frequency developmental abnormalities in p53‐deficient mice. Curr

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