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- Bioss
- bs-8361R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-8361R-AP |
| 英文名称 | LRRC59 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的LRRC59蛋白抗体 |
| 英文别名 | Leucine-rich repeat-containing protein 59; LRC59_HUMAN; LRRC59; PRO1855. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human LRRC59 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Protein Trafficking > ER Proteins |
| 亚基 | Can form homodimers. Interacts with SGOL1. Interacts with FGF1. |
| 亚细胞定位 | Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1. _x000D_ |
| 组织特异性 | Widely expressed. |
| 相似性 | Contains 5 LRR (leucine-rich) repeats. |
| 功能 | Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | LRRC59 (leucine rich repeat containing 59), also known as PRO1855, is a 307 amino acid protein that contains leucine-rich repeats and may play a role in protein binding events throughout the cell. The gene encoding LRRC59 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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LRRC59 Rabbit pAb, AP conjugated(bs-8361R-AP)-100ul
￥2980
