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- Bioss
- bs-11752R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-11752R-Bio |
| 英文名称 | REEP1 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的受体辅助蛋白1抗体 |
| 英文别名 | C2orf23; Chromosome 2 open reading frame 23; FLJ13110; Receptor accessory protein 1; Receptor expression-enhancing protein 1; Reep1; REEP1_HUMAN; SPG31. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human REEP1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease Neuroscience > Sensory System > Olfactory system |
| 亚基 | Interacts with SPAST and ATL1; it preferentiallyinteracts with SPAST isoform 1. Interacts (via C-terminus) withmicrotubules. Interacts with odorant receptor proteins |
| 亚细胞定位 | Membrane. Mitochondrion membrane; Multi-passmembrane protein. Endoplasmic reticulum. |
| 翻译后修饰 | Belongs to the DP1 family. |
| 相似性 | Belongs to the DP1 family. |
| 功能 | May enhance the cell surface expression of odorant receptors. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Transport of G protein-coupled receptors (GPCRs) to the cell surface membrane is critical for receptor-ligand recognition. Mammalian GPCR odorant receptors (ORs), when heterologously expressed in cells, are poorly expressed on the cell surface. REEP1 (receptor expression-enhancing protein 1), is a 201 amino acid multi-pass mitochondrion membrane protein that belongs to the DP1 family. REEP1 interacts with odorant receptor proteins and may enhance the cell surface expression of odorant receptors. Mutations in the REEP1 gene are the third most common cause of hereditary spastic paraplegia (HSP) after spastin and atlastin gene mutations. Mutations in the REEP1 gene also cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. The REEP1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana and rice, and maps to human chromosome 2p11.2. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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REEP1 Rabbit pAb, Biotin conjugated(bs-11752R-Bio)-100ul
￥2980
