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- bsm-41179M-Bio
- 2025年09月30日
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100ul
| 产品编号 | bsm-41179M-Bio |
| 英文名称 | LCN2 Mouse mAb, Biotin conjugated |
| 中文名称 | Biotin标记的脂质运载蛋白单克隆抗体 |
| 英文别名 | Lipocalin 2; Neutrophil Gelatinase associated Lipocalin; 25 kDa alpha 2 microglobulin related subunit of MMP9; alpha 2 microglobulin related protein; HGNC:6526; HNL; Lcn 2; LCN-2; Neutrophil gelatinase associated lipocalin precursor; NGAL; Oncogene 24p3; P25; SV40 induced 24P3 protein. 24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Migration stimulating factor inhibitor; MSFI; Neutrophil gelatinase associated lipocalin precursor; Neutrophil gelatinase-associated lipocalin; NGAL_HUMAN; Oncogenic lipocalin 24p3; Siderocalin; siderocalin LCN2; SV40 induced 24P3 protein. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Mouse |
| 免疫原 | Recombinant human LCN2 |
| 亚型 | IgG1 |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor biomarkers Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Binding proteins Immunology > Adaptive Immunity > T Cells > Non-CD Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Fatty acids Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation Metabolism > Types of disease > Cancer Signal Transduction > Metabolism > Lipid metabolism |
| 亚基 | Homodimer; disulfide-linked. Heterodimer; disulfide-linked with MMP9. |
| 亚细胞定位 | Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized. |
| 组织特异性 | Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. |
| 相似性 | Belongs to the calycin superfamily. Lipocalin family. |
| 功能 | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Lipocalin 2 is a member of the lipocalin family which encompass more than 25 members (including proteins like retinol binding protein, a1 microglobulin, b lactoglobulin, apolipoprotein D and odorant binding protein). The members of the lipocalin family are characterized by their ability to bind small lipophilic substances in their hydrophobic core, and thereby serve as transporters of substances. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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LCN2 Mouse mAb, Biotin conjugated(bsm-41179M-Bio)-100ul
￥2980
