- ￥2980
- Bioss
- bs-12548R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-12548R-Bio |
| 英文名称 | ATP6V0D2 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的ATP6V0D2蛋白抗体 |
| 英文别名 | V-ATPase D2; ATP6D2; ATPase H+transporting lysosomal 38kDa V0 subunit D; ATPase H+transporting lysosomal 38kDa V0 subunit D isoform 2; ATPase H+transporting lysosomal 38kDa V0 subunit D2; FLJ38708; V ATPase subunit d 2; Vacuolar ATP synthase subunit d 2; Vacuolar proton pump subunit d 2; VMA 6; VMA6; VA0D2_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ATP6V0D2/V-ATPase D2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Metabolism > Plasma Membrane > ATPases |
| 亚基 | V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). |
| 亚细胞定位 | Apical plasma membrane. |
| 组织特异性 | Kidney, osteoclast and lung. |
| 相似性 | Belongs to the V-ATPase V0D/AC39 subunit family. |
| 功能 | Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. V-ATPase D2 is a 350 amino acid protein that is expressed in kidney, lung and osteoclast. V-ATPase D2 has been implicated as a regulator of urine acidification, osteoclast fusion and bone formation. Furthermore, V-ATPase D2 has been identified as a dendritic cell marker. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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ATP6V0D2 Rabbit pAb, Biotin conjugated(bs-12548R-Bio)-100ul
￥2980
