ADAM12 Rabbit pAb, PE-Cy5.5 conjugated(bs-5847R-PE-Cy5.5)-100ul

ADAM12 Rabbit pAb, PE-Cy5.5 co

njugated(bs-5847R-PE-Cy5.5)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-5847R-PE-Cy5.5
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      100ul

    产品编号bs-5847R-PE-Cy5.5
    英文名称ADAM12 Rabbit pAb, PE-Cy5.5 conjugated
    中文名称PE-Cy5.5标记的去整合素样金属蛋白酶12抗体
    英文别名A disintegrin and metalloproteinase domain 12; A disintegrin and metalloproteinase domain 12; ADA12_HUMAN; ADAM 12; ADAM metallopeptidase domain 12; Disintegrin and metalloproteinase domain-containing protein 12; MCMP; MCMPMltna; MCMPMltna; Meltrin alpha; Meltrin-alpha; MLTN; MLTNA; OTTHUMP00000046766.
    产品应用Flow-Cyt=3μg/Test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human ADAM12
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Invasion/microenvironment > ECM > Extracellular matrix > ADAM protein family

    Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Metalloprotease > ADAMs

    Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Integrins > Alpha

    Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Integrins > Beta

    Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > ADAM Protein Family

    亚基Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A. Interacts with FST3. Interacts with GNB2L1/RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.
    亚细胞定位Isoform 1: Cell membrane; Single-pass type I membrane protein.
    Isoform 2: Secreted.
    Isoform 3: Secreted (Potential).
    Isoform 4: Secreted (Potential).
    组织特异性Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.
    翻译后修饰The precursor is cleaved by a furin endopeptidase (By similarity).
    相似性Contains 1 disintegrin domain._x000D_
    Contains 1 EGF-like domain._x000D_
    Contains 1 peptidase M12B domain.
    功能Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNF?(tumor necrosis factor ?, and modulation of the neurogenic function of Notch and Delta (1-3). ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail (1-3). ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone, and muscle, and catalyze proteolysis, adhesion, fusion, and intracellular signaling (3). ADAM 12 (Meltrin-a) is produced as 2 differentially spliced isoforms, a 718 amino acid secreted form (ADAM12S) and a 881 amino acid membrane-bound form (ADAM12L), and is involved in egg-sperm fusion (4-6).

     

    应用推荐稀释比例
    {Flow-Cyt}{3μg/Test}

     

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