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- bs-15402R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-15402R-AP |
| 英文名称 | HABP4 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的透明质酸结合蛋白4抗体 |
| 英文别名 | IHABP-4; IHABP4; Intracellular hyaluronan-binding protein 4; Ki-1/57 intracellular antigen; HABP4_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human HABP4 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Interacts with the C-terminus of CHD3. Interacts via its C-terminal region with GNB2L1. Interacts with p53/TP53. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Transported into the nuclear compartment in activated leukocytes. |
| 组织特异性 | Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes. |
| 翻译后修饰 | Phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375 (Probable). |
| 功能 | May be involved in nuclear functions such as the remodeling of chromatin and the regulation of transcription. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The intracellular hyaluronan-binding protein 4 is a cytoplasmic and nuclear protein that is phosphorylated on serine and threonine residues. HABP4 is expressed as a protein of 413 amino acids and is phosphorylated by phorbol 12-myristate 13-acetate (PMA)-activated PKC isoforms at Thr-354 and Thr-375. HABP4 interacts with hyaluron, the adaptor protein RACK1, the transcription factor MEF2C and the chromatin remodeling factor CHD3, suggesting that it may be involved in the regulation of transcription. However, its actual function has yet to be elucidated. HABP4 is highly expressed in brain, heart, and kidney and is moderately expressed in skeletal muscle. Also, HABP4 is expressed in a variety of tumor cell lines and in activated, but not resting, leukocytes. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验SDS-PA gels, and subsequent detection of proteins using rabbit antisera and alkaline phosphatase-conjugated goat-anti-rabbit IgG, detected using bromo-chloro-indolyl phosphate (BCIP) and Nitro-blue tetrazolium (NBT) salts. ・
Developing Genetically Engineered Mouse Models to Study Tumor Suppression
Literature Cited Armstrong, J.F., Kaufman, M.H., Harrison, D.J., and Clarke, A.R. 1995. High‐frequency developmental abnormalities in p53‐deficient mice. Curr
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