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- Bioss
- bs-3296R-HRP
- 2025年12月22日
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100ul
| 产品编号 | bs-3296R-HRP |
| 英文名称 | phospho-PKMYT1 (Ser83) Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的磷酸化蛋白激酶PKMYT1(Ser83)抗体 |
| 英文别名 | Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase; Myt1 kinase; PMYT1_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human PKMYT1 around the phosphorylation site of Ser83 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Cell Cycle > Kinases/Phosphatases Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases |
| 亚基 | Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1. |
| 亚细胞定位 | Endoplasmic reticulum membrane. Golgi apparatus membrane. |
| 翻译后修饰 | Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity. |
| 相似性 | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily._x000D_
Contains 1 protein kinase domain. |
| 功能 | Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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phospho-PKMYT1 (Ser83) Rabbit pAb, HRP conjugated(bs-3296R-HRP)-100ul
￥2980
