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- bs-2525R-AP
- 2025年11月21日
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100ul
| 产品编号 | bs-2525R-AP |
| 英文名称 | CD155 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的脊髓灰质炎病毒受体抗体 |
| 英文别名 | Poliovirus receptor; poliovirus receptor isoform alpha; CD155; FLJ25946; HVED; Necl-5; NECL5; PVS; TAGE4; Taa1; CD155 antigen; Nectin like 5; Nectin like protein 5; Ortholog of mouse Tage4; PVR; PVR_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CD155 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚基 | Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid composed of VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT. |
| 亚细胞定位 | Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Isoform Delta: Cell membrane; Single-pass type I membrane protein. Isoform Beta: Secreted. Isoform Gamma: Secreted. |
| 翻译后修饰 | N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4. |
| 相似性 | Belongs to the nectin family._x000D_
Contains 2 Ig-like C2-type (immunoglobulin-like) domains._x000D_ Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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文献和实验/CD3复合体所特有，它可以不依赖CD3的其它亚单位而存在于NK中，并同FcζγRⅢ（CD16）相连。此外，在TCR触发后，ζ链可以同一胞浆内称为ζ链相关蛋白70（ZAP-70）相结合，AP-70为一种胞浆内具有PTK活性的信号蛋白，含有两个SH-2（src homology region 2,SH-2）结构域以及一个与猪脾中PTK syk相关的激酶结构域，ZAP-70分子中SH-2与ζ链中磷酸化的酪氨酸残基相结合，ζ链的酷氨酸磷酸化是由p59 fyn 或p56 lck
, which mediates the actions of TLR2 and TLR9, was necessary for stimulation by unmethylated DNA or Pam3CSK4, whereas TRIF, which serves as an adaptor for TLR3, was needed for a response to poly-r(I:C). Either adaptor sufficed for stimulation of miR-155
血清10%的RPMI1640培养基培养；嵌合抗CD20 Fab表达载体pYZFcd20由我室构建；大肠杆菌16C9为我室所存；Rituxan购于罗氏公司。2、方法（1）嵌合抗CD20 Fab表达及分离纯化嵌合抗CD20 Fab表达及分离纯化如以前所述[8]，简单说，挑取单菌落pYZFcd20转化的16C9菌株接种5ml含氨苄青霉素50g/ml的2×YT培养基，37℃，200rpm，振荡培养6小时；离心收集菌株，将菌株重新悬浮于20ml含氨苄青霉素50g/ml的AP5培养基，诱导表达培养24小时；离心
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