- ￥5800
- Proteintech
- 84649-2-PBS
- 2025年10月09日
- WB, IF/ICC, Cytometric bead array, Indirect ELISA
- Rabbit
- human
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- 详细信息
- 技术资料
- 免疫原：
Recombinant human Ubiquilin 1 protein
- 亚型：
IgG
- 保存条件：
Store at -80°C.
- 克隆性：
Recombinant
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Rabbit
- 应用范围：
WB, IF/ICC, Cytometric bead array, Indirect ELISA
- 靶点：
Ubiquilin 1
- 抗体英文名：
Ubiquilin 1 Recombinant monoclonal antibody, PBS Only (Capture)
- 抗体名：
Ubiquilin 1 Recombinant monoclonal antibody, PBS Only (Capture)
- 规格：
100ug
产品信息
84649-2-PBS targets Ubiquilin 1 as part of a matched antibody pair:
MP01462-1: 84649-2-PBS capture and 84649-1-PBS detection (validated in Cytometric bead array)
MP01462-2: 84649-2-PBS capture and 84649-3-PBS detection (validated in Cytometric bead array)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| 经测试应用 | WB, IF/ICC, Cytometric bead array, Indirect ELISA |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag17530 Product name: Recombinant human Ubiquilin 1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 324-376 aa of BC010066 Sequence: WAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTAPNLVPGVGASMFNTPG |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | ubiquilin 1 |
| 别名 | UBQLN1, 242092E9, DA41, DSK2, hPLIC 1 |
| 计算分子量 | 589 aa, 63 kDa |
| 观测分子量 | 63-71 kDa |
| GenBank蛋白编号 | BC010066 |
| 基因名称 | Ubiquilin 1 |
| Gene ID (NCBI) | 29979 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q9UMX0 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP (PMID: 21852239). This antibody detects 70kD band of UBQLN1.
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