- ￥1500 - 3280
- Proteintech
- 81180-2-RR
- 2025年10月09日
- WB, ELISA
- Rabbit
- human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Recombinant
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Rabbit
- 应用范围：
WB, ELISA
- 靶点：
Phospho-Paxillin (Tyr118)
- 抗体英文名：
Phospho-Paxillin (Tyr118) Recombinant monoclonal antibody
- 抗体名：
Phospho-Paxillin (Tyr118) Recombinant monoclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2480.0 |
| 规格： | 150ul | 产品价格： | ￥3280.0 |
经过测试的应用
| Positive WB detected in | pervanadate treated HeLa cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:2000-1:10000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
81180-2-RR targets Phospho-Paxillin (Tyr118) in WB, ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, ELISA |
| 经测试反应性 | human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | paxillin |
| 别名 | P Paxillin, P Paxillin (Tyr118), Paxillin (Tyr118), Phospho Paxillin, Phospho Paxillin (Tyr118) |
| 计算分子量 | 591 aa, 65 kDa |
| 观测分子量 | 68 kDa |
| GenBank蛋白编号 | BC136787 |
| 基因名称 | Paxillin |
| Gene ID (NCBI) | 5829 |
| RRID | AB_3670493 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | P49023 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Paxillin (p68-kD) is one of the integrin assembly proteins and can interact directly with several integrin assembly proteins, including vinculin, talin, β1 integrin, focal adhesion kinase (FAK), c-Src and Csk. Integrin-mediated tyrosine phosphorylation also enables paxillin to interact with various signaling molecules: tyrosine residues (Y) 31 and 118 being especially predominant targets of phosphorylation by kinases and creating binding sites for the SH2 domain of adaptor protein Crk. Thus, paxillin plays apivotal role in cell adhesion, migration and further oncogenic transformation. (PMID: 11774284)
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文献和实验Using Phospho‐Motif Antibodies to Determine Kinase Substrates
the phosphorylation site; therefore, substrate?directed, phosphorylation?state?sensitive, motif?specific (?phospho?motif?) antibodies represent powerful tools to identify novel kinase substrates and to investigate mechanisms of substrate phosphorylation
shilei5794749：透明菌落OR 乳白色菌落？ 重组质粒做完转化后，板上长出来的菌落有透明的，有乳白色的．听说重组质粒长出来的菌应该是乳白色的，而透明的菌落很有可能是杂菌？？请问各位战友，这种说法有根据吗？？ 丁香园网友applepie118认为： 这种说法，至少在我作转化来看没有什么根据。 为什么会是乳白色得，难道是插入得片断引起了表型得变化，但是并不是每个插入片断都正好插入到质粒中影响表型得部位，使得颜色变化。所以这句话是一半对一半错，机遇得问题。 举个例子，比如我得质粒
运用Cell Based Elisa检测信号通路蛋白和磷酸化蛋白
using Phospho-p38 antibody (A) and Total-p38 antibody (B). Cell Based Elisa were performed directly in the 96-well plates using Phospho-p38 and Total-p38 antibodies (C). Figure 3: JNK detection with FACECells were serum-starved for 16 hours
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