- ￥1350 - 3000
- Proteintech
- 26155-1-AP
- 2025年10月09日
- WB, IF/ICC, FC (Intra), ELISA
- Rabbit
- mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant mouse Tgfb1 protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
mouse, rat
- 宿主：
Rabbit
- 应用范围：
WB, IF/ICC, FC (Intra), ELISA
- 靶点：
TGF beta 1
- 抗体英文名：
TGF beta 1 Polyclonal antibody
- 抗体名：
TGF beta 1 Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | L-929 cells, NIH/3T3 cells, RAW 264.7 cells, C6 |
| Positive IF/ICC detected in | NIH/3T3 cells |
| Positive FC (Intra) detected in | NIH/3T3 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:200-1:800 |
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
26155-1-AP targets TGF beta 1 in WB, IHC, IF/ICC, FC (Intra), ELISA applications and shows reactivity with mouse, rat samples.
| 经测试应用 | WB, IF/ICC, FC (Intra), ELISA |
| 文献引用应用 | WB, IHC, IF |
| 经测试反应性 | mouse, rat |
| 文献引用反应性 | human, mouse, rat, pig |
| 免疫原 |
CatNo: Ag24078 Product name: Recombinant mouse Tgfb1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 29-390 aa of NM-011577 Sequence: GLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESADPEPEPEADYYAKEVTRVLMVDRNNAIYEKTKDISHSIYMFFNTSDIREAVPEPPLLSRAELRLQRLKSSVEQHVELYQKYSNNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQGDGIQGFRFSAHCSCDSKDNKLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQHLHSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASASPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | transforming growth factor, beta 1 |
| 别名 | Tgfb1, TGFB1,TGF beta 1,TGFbeta,TGF-beta 1, Latency-associated peptide, TGF beta1, Tgfb |
| 观测分子量 | 44 kDa |
| GenBank蛋白编号 | NM-011577 |
| 基因名称 | TGF beta 1 |
| Gene ID (NCBI) | 21803 |
| RRID | AB_3085844 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P04202 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
TGF beta 1 is a potent cytokine capable of regulating multiple cellular processes including cell proliferation, differentiation, wound healing, and immune response. TGF beta 1 is identified in various immune cells and its activity varies in different cell types or cells at different developmental stages1. TGF beta 1 functions by binding to the TGFβ1 receptors, which subsequently activate the canonical SMAD pathway or non-canonical signaling cascades, such as the mitogen-activated protein kinase (MAPK) pathway, phosphatidylinositol-3 kinase and AKT (PI3K-AKT), and Rho family of GTPases (Rho GTPase). What is special about TGF beta 1 is its context-dependent nature that is particularly true for tumors. Full-length, inactive 44 kD TGFB1 is cleaved into mature TGFB1 (13 kD). TGFB1 also homodimerizes and heterodimerizes with TGFB2, so there is potential for multiple different band sizes in WB (12, 25, 45 to 65 kDa).
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文献和实验| Species | Application | Title |
|---|---|---|
| human | WB | Ecotoxicol Environ Saf Ambient fine particulate matter induces cardiac fibrosis through triggering ferroptosis by heme degradation induced-iron overloadAuthors - Jinjin Jiang |
| human | WB | Commun Biol SEC24D depletion induces osteogenic differentiation deficiency by inactivating the ATF6/TGF-β/Runx2 regulatory loopAuthors - Jing Zhang |
| human | WB | Korean Circ J LncRNA uc003pxg.1 Interacts With miR-339-5p Promote Vascular Endothelial Cell Proliferation, Migration and AngiogenesisAuthors - Ping Li |
| pig | WB | Food Funct Sesamin improved growth and overall health in young animals by enhancing gut-liver axis functionAuthors - Chen Chen |
| rat | WB | Front Pharmacol Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degenerationAuthors - Enxu Liu |
| human | WB,IF | Cell Signal The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatmentAuthors - Zucheng Luo |
的解释是 oxLDL刺激后，诸如AP-1\NF-KB不能无限增加，而对抗因素-也就是诸如TGF-beta/Smad3信号通路也相应增强，该信号通路的作用证实抑制AP-1\NF-KB发挥作用。该机制也已被学者所证明。 可是老板却认为同步增强很难解释，非得让我给出一个比较合理的解释。难道我还得重复一次P-Smad3对AP-1\NF-KB的作用才能得到合理的解释？ 必须吗？ 我只求发一篇核心而已 wwdcom2
factor-beta (TGF-β1) and elucidate its mechanism in fibrosis. METHODS: The proliferation, morphology and expression of TGF-β1 of fibroblast was measured by MTT bioassay, HE dyeing and immunocytochemistry. RESULTS: The kwoninone has an could significantly
factor-beta (TGF-β1) and elucidate its mechanism in fibrosis. METHODS: The proliferation, morphology and expression of TGF-β1 of fibroblast was measured by MTT bioassay, HE dyeing and immunocytochemistry. RESULTS: The kwoninone has an could significantly
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