- ￥5800
- Proteintech
- 66093-1-PBS
- 2025年10月09日
- WB, IHC, IF/ICC, IP, Indirect ELISA
- Mouse
- human
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- 详细信息
- 技术资料
- 免疫原：
Recombinant human Caspase 8 protein
- 亚型：
IgG2b
- 保存条件：
Store at -80°C.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Mouse
- 应用范围：
WB, IHC, IF/ICC, IP, Indirect ELISA
- 靶点：
Caspase 8/P43/P18
- 抗体英文名：
Caspase 8/P43/P18 Monoclonal antibody, PBS Only
- 抗体名：
Caspase 8/P43/P18 Monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
66093-1-PBS targets Caspase 8/P43/P18 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, IHC, IF/ICC, IP, Indirect ELISA |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag20524 Product name: Recombinant human Caspase 8 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-270 aa of BC028223 Sequence: MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGTV |
| 宿主/亚型 | Mouse / IgG2b |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | caspase 8, apoptosis-related cysteine peptidase |
| 别名 | CASP8, Caspase 8, 2B9H8, Apoptotic cysteine protease, Apoptotic protease Mch-5 |
| 计算分子量 | 538 aa, 62 kDa |
| 观测分子量 | 53-57 kDa, 32-45 kDa, 18 kDa |
| GenBank蛋白编号 | BC028223 |
| 基因名称 | Caspase 8 |
| Gene ID (NCBI) | 841 |
| RRID | AB_11232214 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q14790 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3 (PMID:21816816). It may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion/caspase-9 pathway (PMID:19194987). Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibody can recognize pro- and cleaved-caspase 8.
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