CoraLite®555-conjugated Phosph
o-STK11/LKB1 (Thr189) Recombinant monoclonal monoclonal antibody CL555-80127- ￥2800
- Proteintech
- CL555-80127
- 2025年10月09日
- IF/ICC, FC (Intra)
- Rabbit
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -20°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Recombinant
- 标记物：
CoraLite®555 Fluorescent Dye
- 适应物种：
human, mouse
- 宿主：
Rabbit
- 应用范围：
IF/ICC, FC (Intra)
- 靶点：
Phospho-STK11/LKB1 (Thr189)
- 抗体英文名：
CoraLite®555-conjugated Phospho-STK11/LKB1 (Thr189) Recombinant monoclonal monoclonal antibody
- 抗体名：
CoraLite®555-conjugated Phospho-STK11/LKB1 (Thr189) Recombinant monoclonal monoclonal antibody
- 规格：
100ul
经过测试的应用
| Positive IF/ICC detected in | Calyculin A treated HeLa cells |
| Positive FC (Intra) detected in | Calyculin A treated PC-3 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Flow Cytometry (FC) (INTRA) | FC (INTRA) : 0.13 ug per 10^6 cells in a 100 µl suspension |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL555-80127 targets Phospho-STK11/LKB1 (Thr189) in IF/ICC, FC (Intra) applications and shows reactivity with human, mouse samples.
| 经测试应用 | IF/ICC, FC (Intra) |
| 经测试反应性 | human, mouse |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | serine/threonine kinase 11 |
| 别名 | p STK11, p STK11 (Thr189), p STK11 Thr189, p STK11/LKB1, p STK11/LKB1 (Thr189) |
| 计算分子量 | 49 kDa |
| 观测分子量 | 50-55 kDa |
| GenBank蛋白编号 | BC007981 |
| 基因名称 | LKB1 |
| Gene ID (NCBI) | 6794 |
| RRID | AB_2934690 |
| 偶联类型 | CoraLite®555 Fluorescent Dye |
| 最大激发/发射波长 | 557 nm / 570 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q15831 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
STK11(serine/threonine-protein kinase 11) is also named as LKB1, PJS, and belongs to the protein kinase superfamily. It controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. The tumour suppressor protein LKB1 is a serine/threonine kinase that has been causally linked to Peutz-Jeghers syndrome (PJS). Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) and defects in STK11 have been associated with testicular germ cell tumor (TGCT) and some sporadic cancers, especially lung cancers.
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文献和实验到 PVDF 膜上，同时减少蛋白不必要降解，这对于最终获得清晰、可信结果也是需要考虑因素。抗体信息：1.ACC1, Recombinant Rabbit monoclonal IgG. HuaAn. HuaAn biotechnology , inc.2.ATGL, Mouse mAb IgG1, Cat#:RT1058. HuaAn biotechnology , inc.3.p-PERK(Thr981), Rabbit Polyclonal IgG primary antibodies, Cat
. Gating based on the negative control shows that 1.8% of cells are CD555‐positive. Side scatter plotted on y axis against intensity of FITC signal on x axis. View Image
Detection of ERK1/2 Activities Using Affinity Reagents
) ( 8 , 9 ). ERK1/2 and p38α bind to the protein tyrosine phosphatase PTP-SL through a kinase interaction motif (KIM) located outside of the protein tyrosine phosphatase (PTP) catalytic domain; on binding, PTP-SL is phosphorylated by these MAPKs, mainly at the Thr
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