- ￥5800
- Proteintech
- 86641-1-PBS
- 2025年10月09日
- WB, Indirect ELISA
- Rabbit
- human
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- 详细信息
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -80°C.
- 克隆性：
Recombinant
- 标记物：
Unconjugated
- 适应物种：
human
- 宿主：
Rabbit
- 应用范围：
WB, Indirect ELISA
- 靶点：
Phospho-STAT6 (Tyr641)
- 抗体英文名：
Phospho-STAT6 (Tyr641) Recombinant monoclonal antibody, PBS Only
- 抗体名：
Phospho-STAT6 (Tyr641) Recombinant monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
86641-1-PBS targets Phospho-STAT6 (Tyr641) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA |
| 经测试反应性 | human |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | signal transducer and activator of transcription 6, interleukin-4 induced |
| 别名 | p STAT6 (Tyr641), Phospho STAT6, Phospho STAT6 (Tyr641), Phospho STAT6(Tyr641), Phospho-STAT6 |
| 计算分子量 | 100 kDa |
| 观测分子量 | 110 kDa |
| GenBank蛋白编号 | BC005823 |
| 基因名称 | STAT6 |
| Gene ID (NCBI) | 6778 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P42226 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
STAT6, also named as Signal transducer and activator of transcription 6, is a 847 amino acid protein, which belongs to the transcription factor STAT family. p-STAT6(Tyr641) is a biomarker of Th2-high inflammation, targeted by IL-4Rα blockers (dupilumab) and JAK1/3 inhibitors. High p-STAT6 in TAMs correlates with M2 polarization and radioresistance, blocking IL-4 or JAK1/3 decreases Tyr641 phosphorylation and restores anti-tumor immunity. (PMID: 37474750)
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