- ￥5800
- Proteintech
- 66952-1-PBS
- 2025年10月09日
- WB, IHC, Indirect ELISA
- Mouse
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human ITGB3 protein
- 亚型：
IgG2b
- 保存条件：
Store at -80°C.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 宿主：
Mouse
- 应用范围：
WB, IHC, Indirect ELISA
- 靶点：
CD61 / Integrin beta 3
- 抗体英文名：
CD61 / Integrin beta 3 Monoclonal antibody, PBS Only
- 抗体名：
CD61 / Integrin beta 3 Monoclonal antibody, PBS Only
- 规格：
100ug
产品信息
66952-1-PBS targets CD61 / Integrin beta 3 in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.
| 经测试应用 | WB, IHC, Indirect ELISA |
| 经测试反应性 | Human |
| 免疫原 |
CatNo: Ag27834 Product name: Recombinant human ITGB3 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 634-718 aa of BC127666 Sequence: CTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPD |
| 宿主/亚型 | Mouse / IgG2b |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
| 别名 | CD61, GP3A, GPIIIa, Integrin beta 3, ITGB3 |
| 计算分子量 | 788 aa, 87 kDa |
| 观测分子量 | 100-110 kDa |
| GenBank蛋白编号 | BC127666 |
| 基因名称 | Integrin beta 3 |
| Gene ID (NCBI) | 3690 |
| RRID | AB_2882275 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P05106 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Integrin beta-3, also named as CD61 and GPIIIa, is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin beta-3 recognize the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen which leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Human integrin beta-3 has a calculated molecular weight of 87 kDa. As a result of glycosylation, the apparent molecular mass of integrin beta-3 is approximately 90-110 kDa.
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文献和实验: 400 mL of PBS x1 + 10 mL of PBS-MgCl2 (MgCm2=4g/L) + 10 mL PBS-CaCl2 (CaCl2= 5.3 g/L) Working Solution of Thrombin = 7 µl of Thrombin (1250U/mL) + 1 mL of Clot Retraction Buffer ADDITIONAL INFO The Clot Retraction
8g/L + dextrose 24.5 g/L NaN3 0.05%-PBS (for 500ml) = 100ml PBS(x 5) + 400ml ddH2 O + 0.25g NaN 3 pH7.0-7.2 PBS (x5)(phosphate buffer saline x5) (for 5L) = 180g NaCl + 37g Na 2 HPO4 *2H 2 O + 10.75g KH2 PO4 + ddHO to 5L
8g/L + dextrose 24.5 g/L NaN3 0.05%-PBS (for 500ml) = 100ml PBS(x 5) + 400ml ddH2 O + 0.25g NaN 3 pH7.0-7.2 PBS (x5)(phosphate buffer saline x5) (for 5L) = 180g NaCl + 37g Na 2 HPO4 *2H 2 O + 10.75g KH2 PO4 + ddHO to 5L
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