Integrin alpha 1 单克隆抗体  68211-1-Ig产品图

Integrin alpha 1 单克隆抗体 68211-

1-Ig
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  • ¥1350 - 3000
  • Proteintech已认证
  • 68211-1-Ig
  • 2026年05月28日
  • WB, IF-P, ELISA
  • Mouse
  • human
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原:

      Recombinant human Integrin alpha-1 protein

    • 亚型:

      IgG2a

    • 保存条件:

      Store at -20°C. Stable for one year after shipment.

    • 克隆性:

      Monoclonal

    • 标记物:

      Unconjugated

    • 适应物种:

      human

    • 宿主:

      Mouse

    • 应用范围:

      WB, IF-P, ELISA

    • 靶点:

      Integrin alpha 1

    • 抗体英文名:

      Integrin alpha 1 Monoclonal antibody

    • 抗体名:

      Integrin alpha 1 Monoclonal antibody

    • 规格:

      50ul/100ul/150ul

    规格:50ul产品价格:¥1350.0
    规格:100ul产品价格:¥2200.0
    规格:150ul产品价格:¥3000.0

    经过测试的应用

    Positive WB detected inHepG2 cells, human placenta tissue
    Positive IF-P detected inhuman placenta tissue
    Planning an IHC experiment? We recommend our IHCeasy Integrin alpha-1 Ready-To-Use IHC Kit. Integrin alpha-1 primary antibody included.

    推荐稀释比

    应用推荐稀释比
    Western Blot (WB)WB : 1:5000-1:50000
    Immunofluorescence (IF)-PIF-P : 1:200-1:800
    It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
    Sample-dependent, Check data in validation data gallery.

    产品信息

    68211-1-Ig targets Integrin alpha 1 in WB, IF-P, ELISA applications and shows reactivity with human samples.

    经测试应用 WB, IF-P, ELISA
    经测试反应性 human
    免疫原

    CatNo: Ag30631

    Product name: Recombinant human Integrin alpha-1 protein

    Source: e coli.-derived, PET28a

    Tag: 6*His

    Domain: 980-1141 aa of BC137121

    Sequence: GNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGYPVLYPTGLSSSENANCRPHIFEDPFSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLTSSDISQVNVSLILWKPTFIKSYFSSLNLTIRGELRSENASLVLSSSNQKRELAIQISKDGLPGRVP

    宿主/亚型 Mouse / IgG2a
    抗体类别 Monoclonal
    产品类型 Antibody
    全称 integrin, alpha 1
    别名 ITGA1, Laminin and collagen receptor, integrin, alpha 1, CD49a, CD49 antigen-like family member A
    计算分子量 1179 aa, 131 kDa
    观测分子量180 kDa
    GenBank蛋白编号BC137121
    基因名称 Integrin alpha 1
    Gene ID (NCBI) 3672
    RRIDAB_2935299
    偶联类型 Unconjugated
    形式Liquid
    纯化方式Protein A purification
    UNIPROT IDP56199
    储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
    储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

    背景介绍

    The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-1 (ITGA1, CD49a) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen and laminin. This receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. Integrin alpha-1 is a transmembrane glycoprotein with an apparent molecular weight of 180-250 kDa, larger than the calculated molecular weight of 131 kDa (PMID: 2475259; 3257425; 11557277; 18840653).

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    图标文献和实验
    相关实验
    • 免疫球蛋白[Ig]超家族的结构和功能特点

      -3,CD4与MHC Ⅱ类分子的单态部分(α2和β2),CD8与MHCⅠ类分子的单态部分(α3),Poly IgR与多聚Ig,FcγRⅠ(CD64)、FcγRⅡ(CD32)、FcγRⅢ(CD16)与Ig Fc段,FcεRⅠ与IgE Fc段,FcαR(CD89)与IgA Fc段,CD28与B7/BB1(CD80)等之间的相互识别。   2.IGSF和integrin相互识别 

    • CD11a/CD11b/CD11c分子

      associated alpha and beta subunits   CD11a Aka alpha L; LFA-1 (in complex with CD18) An alpha integrin chain that binds to CD18 and mediates leukocyte adhesion and lymphocyte recirculation through lymph

    • CD79a/CD79b分子

      CD79a Encodes the Ig-alpha protein of the B-cell antigen receptor; receptor also includes Ig-beta protein, surface immunoglobulin Expressed early in B-cell differentiation (often positive when mature B-cell markers are negative

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