CoraLite® Plus 488-conjugated BBS4 重组单克隆抗体  CL488-82961

CoraLite® Plus 488-conjugated

BBS4 重组单克隆抗体 CL488-82961
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  • ¥2800
  • Proteintech已认证
  • CL488-82961
  • 2025年10月09日
  • IF/ICC, FC (Intra)
  • Rabbit
  • human
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    • 详细信息
    • 技术资料
    • 免疫原

      Recombinant human BBS4 protein

    • 亚型

      IgG

    • 保存条件

      Store at -20°C. Avoid exposure to light. Stable for one year after shipment.

    • 克隆性

      Recombinant

    • 标记物

      CoraLite® Plus 488 Fluorescent Dye

    • 适应物种

      human

    • 宿主

      Rabbit

    • 应用范围

      IF/ICC, FC (Intra)

    • 靶点

      BBS4

    • 抗体英文名

      CoraLite® Plus 488-conjugated BBS4 Recombinant monoclonal antibody

    • 抗体名

      CoraLite® Plus 488-conjugated BBS4 Recombinant monoclonal antibody

    • 规格

      100ul

    经过测试的应用

    Positive IF/ICC detected inhTERT-RPE1 cells
    Positive FC (Intra) detected inHeLa cells
    Planning an IHC experiment? We recommend our IHCeasy BBS4 Ready-To-Use IHC Kit. BBS4 primary antibody included.
    For other applications, we recommend the unconjugated version of this antibody, 82961-1-PBS

    推荐稀释比

    应用推荐稀释比
    Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
    Flow Cytometry (FC) (INTRA)FC (INTRA) : 0.80 ug per 10^6 cells in a 100 µl suspension
    It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
    Sample-dependent, Check data in validation data gallery.

    产品信息

    CL488-82961 targets BBS4 in IF/ICC, FC (Intra) applications and shows reactivity with human samples.

    经测试应用 IF/ICC, FC (Intra)
    经测试反应性 human
    免疫原

    CatNo: Ag3430

    Product name: Recombinant human BBS4 protein

    Source: e coli.-derived, PGEX-4T

    Tag: GST

    Domain: 1-351 aa of BC027624

    Sequence: MAEERVATRTQFPVSTESQKPRQKKAPEFPILEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNL

    宿主/亚型 Rabbit / IgG
    抗体类别 Recombinant
    产品类型 Antibody
    全称 Bardet-Biedl syndrome 4
    别名 Bardet-Biedl syndrome 4 protein, Bardet Biedl syndrome 4, 230303C2
    计算分子量 519 aa, 58 kDa
    观测分子量60 kDa
    GenBank蛋白编号BC027624
    基因名称 BBS4
    Gene ID (NCBI) 585
    RRIDAB_3673154
    偶联类型 CoraLite® Plus 488 Fluorescent Dye
    最大激发/发射波长493 nm / 522 nm
    形式Liquid
    纯化方式Protein A purification
    UNIPROT IDQ96RK4
    储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
    储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

    背景介绍

    BBS4 (Bardet-Biedl syndrome protein 4) is one of the early BBS proteins discovered, with 35 mutations reported to cause the BBS phenotype (PMID: 26762677). BBS4 undergoes localization to the centriolar satellites of centrosomes and basal body of primary cilia, where it takes part in recruiting cargo to centriolar satellites and allowing the formation of a functional centrosomal microtubule organizing center (MTOC) (PMID: 25860617). Some research has found that BBS4 expression in humans during the development of CNS and sensory organs, concerning the cardinal clinical signs of BBS (PMID: 33860840).

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