- ￥1000 - 2540
- Proteintech
- 65189-1-Ig
- 2025年10月09日
- FC
- Rat
- mouse
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- 详细信息
- 技术资料
- 亚型：
IgG1, kappa
- 保存条件：
Store at 2-8°C. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
mouse
- 宿主：
Rat
- 应用范围：
FC
- 靶点：
CD41
- 抗体英文名：
Anti-Mouse CD41 (MWReg30)
- 抗体名：
Anti-Mouse CD41 (MWReg30)
- 规格：
100ug/500ug
| 规格： | 100ug | 产品价格： | ￥1000.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥2540.0 |
经过测试的应用
| Positive FC detected in | C57BL/6 mouse peripheral blood platelets |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) | FC : 0.5 ug per 10^6 cells in 100 μl suspension |
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
65189-1-Ig targets CD41 in FC applications and shows reactivity with mouse samples.
| 经测试应用 | FC |
| 经测试反应性 | mouse |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rat / IgG1, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | integrin alpha 2b |
| 别名 | Itga2b, GpIIb, integrin alpha 2b, MWReg30 |
| GenBank蛋白编号 | BC120493 |
| 基因名称 | CD41 |
| Gene ID (NCBI) | 16399 |
| RRID | AB_3084902 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Purified by protein-G affinity chromatography |
| UNIPROT ID | Q9QUM0 |
| 储存缓冲液 | PBS with 0.09% sodium azide, pH 7.3. |
| 储存条件 | Store at 2-8°C. Stable for one year after shipment. |
背景介绍
The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen.
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