- ￥2150 - 6660
- Proteintech
- 65241-1-Ig
- 2025年10月09日
- IF-P, FC
- Rat
- human, mouse, canine
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG1, kappa
- 保存条件：
Store at 2-8°C. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, canine
- 宿主：
Rat
- 应用范围：
IF-P, FC
- 靶点：
E-cadherin
- 抗体英文名：
Anti-Mouse E-cadherin (DECMA-1)
- 抗体名：
Anti-Mouse E-cadherin (DECMA-1)
- 规格：
100ug/500ug
| 规格： | 100ug | 产品价格： | ￥2150.0 |
|---|---|---|---|
| 规格： | 500ug | 产品价格： | ￥6660.0 |
经过测试的应用
| Positive IF-P detected in | mouse colon tissue |
| Positive FC detected in | MDCK cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunofluorescence (IF)-P | IF-P : 1:625-1:2500 |
| Flow Cytometry (FC) | FC : 0.2 ug per 10^6 cells in 100 μl suspension |
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
65241-1-Ig targets E-cadherin in IF-P, FC applications and shows reactivity with human, mouse, canine samples.
| 经测试应用 | IF-P, FC |
| 经测试反应性 | human, mouse, canine |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rat / IgG1, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | cadherin 1 |
| 别名 | CD324 (E-cadherin), cadherin 1, Cdh1, Ecad, L CAM |
| GenBank蛋白编号 | BC098501 |
| 基因名称 | E-cadherin |
| Gene ID (NCBI) | 12550 |
| RRID | AB_2935150 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Affinity purification |
| UNIPROT ID | P09803 |
| 储存缓冲液 | PBS with 0.09% sodium azide, pH 7.3. |
| 储存条件 | Store at 2-8°C. Stable for one year after shipment. |
背景介绍
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice(PMID:23509752). E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.
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