- ￥1210 - 3020
- Proteintech
- CL750-65102
- 2025年10月09日
- FC
- Rat
- mouse
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- 详细信息
- 技术资料
- 亚型：
IgG2b, kappa
- 保存条件：
Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Monoclonal
- 标记物：
CoraLite® Plus 750 Fluorescent Dye
- 适应物种：
mouse
- 宿主：
Rat
- 应用范围：
FC
- 靶点：
GITR/TNFRSF18
- 抗体英文名：
CoraLite® Plus 750 Anti-Mouse GITR/TNFRSF18 (DTA-1)
- 抗体名：
CoraLite® Plus 750 Anti-Mouse GITR/TNFRSF18 (DTA-1)
- 规格：
25ug/100ug
| 规格： | 25ug | 产品价格： | ￥1210.0 |
|---|---|---|---|
| 规格： | 100ug | 产品价格： | ￥3020.0 |
经过测试的应用
| Positive FC detected in | mouse splenocytes |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Flow Cytometry (FC) | FC : 0.5 ug per 10^6 cells in 100 μl suspension |
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL750-65102 targets GITR/TNFRSF18 in FC applications and shows reactivity with mouse samples.
| 经测试应用 | FC |
| 经测试反应性 | mouse |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rat / IgG2b, kappa |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | tumor necrosis factor receptor superfamily, member 18 |
| 别名 | CD357, GITR, Tnfrsf18, AITR, Glucocorticoid-induced TNFR-related protein |
| GenBank蛋白编号 | BC146517 |
| 基因名称 | CD357 |
| Gene ID (NCBI) | 21936 |
| RRID | AB_3084846 |
| 偶联类型 | CoraLite® Plus 750 Fluorescent Dye |
| 最大激发/发射波长 | 755 nm / 780 nm |
| 形式 | Liquid |
| 纯化方式 | Affinity purification |
| UNIPROT ID | O35714 |
| 储存缓冲液 | PBS with 0.09% sodium azide, pH 7.3. |
| 储存条件 | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
背景介绍
Glucocorticoid-induced TNFR-related protein (GITR), also known as CD357 or TNFRSF18, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is expressed constitutively at high levels in T regulatory cells (Treg cells) and plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells (PMID: 11812990). It is expressed at low levels on resting responder T cells. The expression of GITR on T cells can be upregulated upon activation (PMID: 15770698). GITR is activated by GITR ligand (GITRL) which is mainly expressed on APC. GITR-GITRL interactions could co-stimulate both responder T-cell functions and the suppressive functions of Treg cells (PMID: 16868552).
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