- ￥2800
- Proteintech
- CL488-80488
- 2025年10月09日
- IF/ICC
- Rabbit
- Human, Pig, Mouse, Rat, Zebrafish
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 保存条件：
Store at -20°C. Avoid exposure to light. Stable for one year after shipment.
- 克隆性：
Recombinant
- 标记物：
CoraLite® Plus 488 Fluorescent Dye
- 适应物种：
Human, Pig, Mouse, Rat, Zebrafish
- 宿主：
Rabbit
- 应用范围：
IF/ICC
- 靶点：
Beta Catenin
- 抗体英文名：
CoraLite® Plus 488-conjugated Beta Catenin Recombinant monoclonal antibody
- 抗体名：
CoraLite® Plus 488-conjugated Beta Catenin Recombinant monoclonal antibody
- 规格：
100ul
经过测试的应用
| Positive IF/ICC detected in | MCF-7 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL488-80488 targets Beta Catenin in IF/ICC applications and shows reactivity with Human, Pig, Mouse, Rat, Zebrafish samples.
| 经测试应用 | IF/ICC |
| 经测试反应性 | Human, Pig, Mouse, Rat, Zebrafish |
| 免疫原 |
fusion protein |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | catenin (cadherin-associated protein), beta 1, 88kDa |
| 别名 | b cat, Beta catenin, Catenin beta 1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, PRO2286 |
| 计算分子量 | 781 aa, 86 kDa |
| 观测分子量 | 92 kDa |
| GenBank蛋白编号 | BC058926 |
| 基因名称 | Beta Catenin |
| Gene ID (NCBI) | 1499 |
| ENSEMBL Gene ID | ENSG00000168036 |
| RRID | AB_2934628 |
| 偶联类型 | CoraLite® Plus 488 Fluorescent Dye |
| 最大激发/发射波长 | 493 nm / 522 nm |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P35222 |
| 储存缓冲液 | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)
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文献和实验Systemor equivalent). 4. Nitrocellulose or polyvinyl difluoride (PVDF) membrane. 5. Wnt3A antibody (available from R&D Systems, Minneapolis,MN). 6. Appropriate conjugated secondary antibody for detection. 2.4.2. b-Catenin Stabilization
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