- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K114851P
- 2025年08月22日
- WB;IHC
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein of human ARID5A
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze / thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human
- 抗原来源：
Recombinant protein of human ARID5A
- 目录编号：
10865
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB;IHC
- 浓度：
WB 1:1000-3000.IHC 1:50-200.
- 靶点：
ARID5A
- 抗体英文名：
Anti-ARID5A Polyclonal Antibody
- 抗体名：
富含AT交互结构域蛋白5A（MRF1样）
- 规格：
20ul/100ul/50ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 基本信息 | |
| 英文名称 | Anti-ARID5A Polyclonal Antibody |
| 中文名称 | 富含AT交互结构域蛋白5A（MRF1样） |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Mouse;Human |
| 应用 | IHC;WB |
| 稀释比例 | WB 1:1000-3000.IHC 1:50-200. |
| 密度 | |
| 靶标 | ARID5A |
| 别名 | ARID domain containing protein 5A;ARID-containing protein 5A;AT rich interactive domain 5A;AT rich interactive domain 5A (MRF1 like);AT rich interactive domain containing protein 5A;Modulator recognition factor 1;MRF 1;MRF1;RFVG5814;RP11 363D14; |
| 背景说明 | Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988).May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity).Can repress ESR1-mediated transcriptional activation;proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852).As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs;at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity).Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR;thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). |
| Swiss Prot | Q03989 |
| Gene ID | 10865 |
| 亚细胞定位 | Nucleus |
| 免疫原 | Recombinant protein of human ARID5A |
| Public Immunogen Range | 1-347aa |
| 理论分子量 | 57/64kDa |
| 实际分子量 | 62kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol, 0.03% Proclin300, 0.5% BSA, pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze / thaw cycles. |
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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