Rabbit anti-IL10 Polyclonal An

别名：兔抗IL10多克隆抗体

免疫原：A synthesized peptide derived from Human IL10(Accession P22301), corresponding to amino acid residues G113-V142.

应用：WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:100-1:500, ELISA(peptide): 1:20000-1:40000

保持条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

使用方法：WB,IHC,IF,ELISA

标记：Unlabeled

宿主：Rabbit

反应种属：Human;Mouse;Rat

克隆性：见优宁维官网

产品描述：

IL-10 is an anti-inflammatory cytokine that is produced by T cells, NK cells and macrophages (1,2). IL-10 initiates signal transduction by binding to a cell surface receptor complex consisting of IL-10 RI and IL-10 RII (1). Binding of IL-10 leads to the activation of Jak1 and Tyk2, which phosphorylates Stat-3 (1,3). The anti-inflammatory activity of IL-10 is due to its ability to block signaling through other cytokine receptors, notably IFNγ receptor, by upregulating expression of SOCS-1 (1,3). In addition, IL-10 promotes T cell tolerance by inhibiting tyrosine phosphorylation of CD28 (4,5). IL-10 is an important negative regulator of the immune response, which allows for maintenance of pregnancy (1). In contrast, increased IL-10 levels contribute to persistent Leishmania major infections (6).

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