K117572P Anti-RNF25 Polyclonal

E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway， a pathway that takes place when a ribosome has stalled during translation， and which promotes ubiquitination and degradation of translation factors on stalled ribosomes.RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes， such as RPL0， RPL1， RPL12， RPS13 and RPS17.Also involved in ubiquitination and degradation of stalled ETF1/eRF1.Independently of its function in the response to stalled ribosomes， mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65.