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Anti-Phospho-Tuberin / TSC2 (S

er939) Recombinant Rabbit Monoclonal Ab
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  • ¥860
  • Elucigen Biosciences
  • ERB0668
  • 2025年08月13日
  • ICC, IHC, WB
  • Rabbit
  • Human, Mouse (predicted), Rat (predicted)
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  • 企业认证

    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide corresponding to the amino acids surrounding phosphoserine 939 of human TSC2.

    • 亚型

      IgG

    • 形态

      Liquid

    • 保存条件

      -20°C

    • 克隆性

      Monoclonal

    • 标记物

      Unconjugated

    • 适应物种

      Human, Mouse (predicted), Rat (predicted)

    • 保质期

      12 months from the shipping date of the product.

    • 抗原来源

      Human

    • 目录编号

      ERB0668

    • 级别

      Primary Antibodies

    • 库存

      Available

    • 供应商

      Elucigen Biosciences

    • 宿主

      Rabbit

    • 应用范围

      ICC, IHC, WB

    • 浓度

      0.5 mg/mL

    • 靶点

      P49815

    • 抗体英文名

      Anti-Phospho-Tuberin / TSC2 (Ser939) Recombinant Rabbit Monoclonal Ab

    • 抗体名

      Anti-Phospho-Tuberin / TSC2 (Ser939) Recombinant Rabbit Monoclonal Ab

    • 规格

      25μg/100μg/500μg

    规格:25μg产品价格:¥860.0
    规格:100μg产品价格:询价
    规格:500μg产品价格:询价
    Phospho-Tuberin (Ser939 plays a pivotal role in regulating the activity of the TSC1/TSC2 complex, a critical inhibitor of mTORC1 signaling pathway, which governs cell growth, proliferation, and metabolism. Phosphorylation at Ser939 is primarily mediated by the serine/threonine kinase Akt in response to growth factors and insulin signaling. This modification facilitates the binding of Tuberin to 14-3-3 proteins, leading to the inhibition of the TSC1/TSC2 complex's GTPase-activating protein (GAP) activity toward the small GTPase Rheb. Consequently, Rheb remains in its active GTP-bound state, promoting mTORC1 activation and downstream anabolic processes.

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    图标文献和实验
    该产品被引用文献
    Sparagana, S.P. and Roach, E.S. (2000) Curr Opin Neurol 13, 115-9.
    相关实验
    • v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平

      4 ). 2. Other antibodies used were b-catenin (phospho-Thr41/Ser37/Ser33) (#9561; Cell Signaling Technology), b-catenin (#9562;Cell Signaling Technology), CRMP2 (pT514/509) (#PB-043; Kinasource, Dundee, Scotland) and CRMP2 (#AB-042;Kinasource). 3. Blocking buffer

    • Purification, Characterization, and Biotinylation of Single-Chain Antibodies

      with the corresponding scFv containing a VH -(Gly4 Ser)3 -VL linker has shown no perturbation of the folding of the variable domains by the linker (4 ,5 ). In comparison to the much larger Fab′, F(ab′)2 , and IgG forms of monoclonal antibody (MAb

    • Indirect Immunofluorescence

      Reagents:  NGS-Normal Goat Serum  PBST-0.5% Tween-20/CMF-PBS  CMF-PBS  1°Ab-mouse MF20 (anti-myosin monoclonal)  1°Ab-rabbit myoD (anti-myoD polyclonal)  2°Ab-goat anti-mouse IgG-FITC  2°Ab-goat anti-rabbit IgG-FITC

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    文献支持
    Anti-Phospho-Tuberin / TSC2 (Ser939) Recombinant Rabbit Monoclonal Ab
    ¥860