- ￥860
- Elucigen Biosciences
- ERB0599
- 2025年08月13日
- IHC, WB
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Synthetic peptide corresponding to the amino acids surrounding phosphoserine 396 at the C-terminal region of human IRF-3.
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
-20°C
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
12 months from the shipping date of the product.
- 抗原来源：
Human
- 目录编号：
ERB0599
- 级别：
Primary Antibodies
- 库存：
Available
- 供应商：
Elucigen Biosciences
- 宿主：
Rabbit
- 应用范围：
IHC, WB
- 浓度：
0.5 mg/mL
- 靶点：
Q14653
- 抗体英文名：
Anti-Phospho-IRF-3 (Ser396) Recombinant Rabbit Monoclonal Ab
- 抗体名：
Anti-Phospho-IRF-3 (Ser396) Recombinant Rabbit Monoclonal Ab
- 规格：
25μg/100μg/500μg
| 规格： | 25μg | 产品价格： | ￥860.0 |
|---|---|---|---|
| 规格： | 100μg | 产品价格： | 询价 |
| 规格： | 500μg | 产品价格： | 询价 |
Interferon Regulatory Factors (IRFs) are a family of transcription factors that play crucial roles in the regulation of the immune response, particularly in the expression of type I interferons and other cytokines. Among them, IRF3 is a key mediator in the innate immune response to viral infections. A critical post-translational modification of IRF3 involves the phosphorylation at serine residue 396 (Ser396). This phosphorylation event is essential for the activation of IRF3. Upon viral infection, kinases such as TBK1 and IKKε phosphorylate IRF3 at Ser396, among other sites, leading to a conformational change that promotes IRF3 dimerization. The dimerized IRF3 then translocates into the nucleus, where it associates with coactivators like CBP/p300 to initiate the transcription of interferon-stimulated genes (ISGs) and type I interferons, thereby mounting an effective antiviral response.
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文献和实验该产品被引用文献
Honda, K. and Taniguchi, T. (2006) Nat Rev Immunol 6, 644-58.
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Anti-Phospho-IRF-3 (Ser396) Recombinant Rabbit Monoclonal Ab
￥860
