Anti-COX2 / PTGS2 Recombinant

Cyclooxygenase-2 (COX-2), encoded by the PTGS2 gene, is an inducible enzyme involved in the biosynthesis of prostaglandins, which are lipid signaling molecules that play key roles in inflammation, pain, fever, and tissue homeostasis. It is one of two major isoforms of cyclooxygenase, the other being the constitutively expressed COX-1. Unlike COX-1, which is expressed in most tissues for routine physiological functions, COX-2 is typically low or absent under normal conditions but is rapidly upregulated in response to pro-inflammatory stimuli, such as cytokines, growth factors, and tumor promoters. Once activated, COX-2 catalyzes the conversion of arachidonic acid to prostaglandin H2 (PGH2), a precursor of various biologically active prostaglandins. Due to its strong association with inflammation and cancer, COX-2 is a prominent target in the development of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly COX-2 selective inhibitors (like celecoxib), which aim to reduce inflammation and pain while minimizing gastrointestinal side effects linked to COX-1 inhibition.