Anti-IRE1α / ERN1 Recombinant

​Serine/threonine-protein kinase/endoribonuclease IRE1 (IRE1α) is a pivotal transmembrane sensor of the unfolded protein response (UPR) in the endoplasmic reticulum (ER). Encoded by the ERN1 gene, IRE1α possesses dual enzymatic activities: a serine/threonine kinase and an endoribonuclease. Upon accumulation of misfolded proteins in the ER lumen, IRE1α undergoes oligomerization and trans-autophosphorylation, activating its endoribonuclease function. This activation leads to the unconventional splicing of X-box binding protein 1 (XBP1) mRNA, producing a potent transcription factor, XBP1s, which upregulates genes involved in protein folding, secretion, and degradation to restore ER homeostasis . Additionally, IRE1α mediates regulated IRE1-dependent decay (RIDD) of select mRNAs, modulating protein synthesis and contributing to cellular adaptation or apoptosis under prolonged ER stress . Beyond its canonical roles, IRE1α influences various physiological processes, including lipid metabolism, inflammation, and neurodevelopment, and its dysregulation has been implicated in diseases such as cancer, diabetes, and neurodegenerative disorders .​