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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Synthetic peptide corresponding to the amino acids surrounding phosphoserine 486 at the internal region of human HDAC7.
- 亚型:
IgG
- 形态:
Liquid
- 保存条件:
-20°C
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Human
- 目录编号:
ERB0608
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
Elucigen Biosciences
- 宿主:
Rabbit
- 应用范围:
ICC, IHC, WB
- 浓度:
0.5 mg/mL
- 靶点:
Q8WUI4
- 抗体英文名:
Anti-Phospho-HDAC7 (Ser486) Recombinant Rabbit Monoclonal Ab
- 抗体名:
Anti-Phospho-HDAC7 (Ser486) Recombinant Rabbit Monoclonal Ab
- 规格:
25μg/100μg/500μg
| 规格: | 25μg | 产品价格: | ¥860.0 |
|---|---|---|---|
| 规格: | 100μg | 产品价格: | 询价 |
| 规格: | 500μg | 产品价格: | 询价 |
HDAC7 is a class IIa histone deacetylase involved in transcriptional repression by removing acetyl groups from histone proteins, leading to chromatin condensation and gene silencing. Phosphorylation at Ser486 plays a crucial role in regulating HDAC7's subcellular localization and function. Specifically, phosphorylation at this site facilitates the binding of 14-3-3 proteins, promoting the nuclear export of HDAC7 to the cytoplasm. This translocation relieves HDAC7-mediated transcriptional repression, thereby modulating gene expression in response to various cellular signals. Such regulation is essential in processes like muscle differentiation and T-cell development.
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文献和实验该产品被引用文献
Gregory, P.D. et al. (2001) Exp Cell Res 265, 195-202.
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Anti-Phospho-HDAC7 (Ser486) Recombinant Rabbit Monoclonal Ab
¥860






