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Anti-MDM2 Recombinant Rabbit M

onoclonal Ab
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  • ¥860
  • Elucigen Biosciences
  • ERB0438
  • 2025年08月13日
  • IHC, WB
  • Rabbit
  • Human, Mouse
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  • 企业认证

    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Synthetic peptide corresponding to the N-terminal region of human MDM2.

    • 亚型

      IgG

    • 形态

      Liquid

    • 保存条件

      -20°C

    • 克隆性

      Monoclonal

    • 标记物

      Unconjugated

    • 适应物种

      Human, Mouse

    • 保质期

      12 months from the shipping date of the product.

    • 抗原来源

      Human

    • 目录编号

      ERB0438

    • 级别

      Primary Antibodies

    • 库存

      Available

    • 供应商

      Elucigen Biosciences

    • 宿主

      Rabbit

    • 应用范围

      IHC, WB

    • 浓度

      0.5 mg/mL

    • 靶点

      Q00987

    • 抗体英文名

      Anti-MDM2 Recombinant Rabbit Monoclonal Ab

    • 抗体名

      Anti-MDM2 Recombinant Rabbit Monoclonal Ab

    • 规格

      25μg/100μg/500μg

    规格:25μg产品价格:¥860.0
    规格:100μg产品价格:询价
    规格:500μg产品价格:询价
    MDM2 (Murine Double Minute 2) is an important negative regulator of the p53 tumor suppressor protein. It is an E3 ubiquitin ligase that binds to p53, promoting its degradation by the proteasome, and thereby controlling the levels of p53 in cells. MDM2 plays a critical role in the regulation of the cell cycle, DNA repair, and apoptosis, mainly by inhibiting p53's function as a transcription factor that activates genes involved in these processes. Beyond its role in p53 regulation, MDM2 is also involved in the modulation of various signaling pathways, including those related to cell growth and survival. Dysregulation of MDM2, such as overexpression or mutations, can lead to impaired p53 function, contributing to tumorigenesis and the development of various cancers. As such, MDM2 is a key target in cancer research, with potential for therapeutic interventions aimed at restoring p53 activity.

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    图标文献和实验
    该产品被引用文献
    Haupt, Y. et al. (1997) Nature 387, 296-299.
    相关实验
    • 【求助】抗体名称Ab-33是什么意思?

      around the phosphorylation site of serine 33 (L-D-SP-G-I)。 http://www.genscript.com/product_001/rec_antibody/code/A00584/category/antibody/Rabbit_Anti_beta-Catenin_Ab-33_polyclonal.html bettyzyj http://www.signalwayantibody.com/resurgam/uppdf/21211.pdf

    • Anti-HA Immunocytology

      monoclonal anti-HA 16B12 (MMS101R, BAbCo, used at 1:200 to 1:1000 dilution) mouse monoclonal anti-HA 12CA5 (12CA5, Boehringer, used at 1:200 dilution) rabbit polyclonal anti-HA (RS1010C, BAbCo, used at 1:200 dilution) Cy3-conjugated affinity

    • Anti-HA Immunocytology

      until examination. Antibodies mouse monoclonal anti-HA 16B12 (MMS101R, BAbCo, used at 1:200 to 1:1000 dilution) mouse monoclonal anti-HA 12CA5 (12CA5, Boehringer, used at 1:200 dilution) rabbit polyclonal anti-HA (RS1010C, BAbCo, used

    图标技术资料

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    文献支持
    Anti-MDM2 Recombinant Rabbit Monoclonal Ab
    ¥860