Anti-α-Dystroglycan Recombinan

Alpha-dystroglycan (α-DG) is a glycoprotein that plays a key role in the dystrophin-glycoprotein complex (DGC), which is essential for maintaining the structural integrity of muscle cells and other tissues. α-DG is the extracellular subunit of the dystroglycan complex and functions as a receptor that binds to the extracellular matrix (ECM), particularly to laminin, a key protein in the basement membrane. This interaction helps to stabilize muscle cell membranes and facilitate communication between the intracellular cytoskeleton and the ECM. α-DG is heavily glycosylated at its extracellular domain, and these glycosylation modifications are critical for its function, enabling it to interact with ECM components. Mutations or defects in α-DG's structure or glycosylation can lead to muscular dystrophies and other related disorders, such as limb-girdle muscular dystrophy and Walker-Warburg syndrome. These conditions are often characterized by muscle weakness, defects in tissue architecture, and impaired cellular signaling.