Anti-TPH1 / Tryptophan 5-hydro

Tryptophan 5-hydroxylase 1 (TPH1) is an enzyme that catalyzes the rate-limiting step in the biosynthesis of serotonin, an important neurotransmitter involved in mood regulation, digestion, and various other physiological processes. TPH1 specifically converts the amino acid tryptophan into 5-hydroxytryptophan, which is subsequently decarboxylated to form serotonin. TPH1 is primarily expressed in peripheral tissues, such as the gastrointestinal tract, and is distinct from TPH2, which is found in the brain. Given its role in serotonin production, TPH1 is a key player in regulating serotonin levels in the body, with implications for mood disorders, gastrointestinal function, and other serotonin-related conditions. Research into TPH1 focuses on its regulation, its role in serotonin synthesis, and its potential as a therapeutic target for disorders like depression, irritable bowel syndrome (IBS), and other serotonin-related diseases.