- ￥2544.48
- BioLegend
- 905701
- 美国
- 2025年08月12日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
Purified anti-Mouse Keratin 6A
- 抗体英文名：
Purified anti-Mouse Keratin 6A
- 供应商：
上海善然生物科技有限公司
- 保存条件：
2-8℃
- 规格：
100ul
Purified anti-mouse Keratin 6A Antibody (Previously Covance catalog# PRB-169P)
Poly19057
Catalog# / Size
905701 / 100 µL
Clone
Regulatory Status RUO
Other Names Keratin, type II cytoskeletal 6A, K6A, CK-6A, mK6-alpha, keratin-6A, 60-kD keratin, cytokeratin-6A,
keratin-6-alpha
Previously Covance Catalog# PRB-169P
Isotype Rabbit Polyclonal IgG
Description Keratin 6A is a type II cytokeratin that belongs to the keratin family of fibrous structural proteins. The
protein is expressed along with its partners KRT16 and/or KRT17 in the filiform papillae of the tongue,
the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and
the glandular epithelia. The murine genome is known to have two keratin 6 (CK6) genes, CK6A and
CK6b. Mutations in these genes have been associated with pachyonychia congenita.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Nat Commun：肖东/孙妍课题组合作揭示 m6A 修饰调节细胞自噬的新机制
的 RNA 修饰可响应不断变化的营养信号实现迅速的基因表达调控，对自噬发挥重要影响，并且一些表观转录组成员在此过程中可能发挥关键作用。 该研究首先基于原代分离的小鼠胚胎成纤维细胞 (mouse embryonic fibroblasts, MEFs)，通过蛋白组学检测，发现在营养缺乏期间，m6A 阅读器 YTHDF3 表达显著上调（图 1a）。进一步的分子和细胞功能实验表明，YTHDF3 对自噬诱导至关重要，YTHDF3 过表达促进营养缺乏时自噬体形成和溶酶体降解（图 1c-l）。 图
-purified goat anti-mouse IgG (Jackson Labs; 1 mg/ml stock used at 1:300 dilution) Texas Red-conjugated affinity-purified donkey anti-rabbit (Jackson Labs;1 mg/ml stock used at 1:200 dilution)
of yet unidentified modifier genes on the phenotype after the ablation of the respective keratin. To date, nearly all available keratin mouse models were generated by taking advantage of conventional gene-targeting strategies. To reveal their cell type
技术资料暂无技术资料 索取技术资料
