- ￥2000 - 3200
- Solarbio|ElaBoX
- 12.5-800pg/mL
- 6.25pg/mL
- SEKM-0224
- 北京
- 2025年08月13日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 检测范围：
12.5-800pg/mL
- 检测方法：
ELISA
- 应用：
ELISA
- 适应物种：
Mouse
- 标记物：
OSM
- 样本：
血清/血浆/细胞培养上清
- 灵敏度：
6.25pg/mL
- 规格：
96T/48T
| 规格： | 96T | 产品价格： | ￥3200.0 |
|---|---|---|---|
| 规格： | 48T | 产品价格： | ￥2000.0 |
| 基本信息 | |
| 中文名称 | 小鼠抑瘤素M检测试剂盒 |
| 英文名称 | Mouse Oncostatin M ELISA Kit |
| 别名 | Oncostatin M; OSM; MGC20461; Oncostatin-M |
| 储存条件 | 2-8℃，6 months |
| 检测目标 | OSM |
| 样品类型 | 血清/血浆/细胞培养上清 |
| 反应性 | Mouse |
| 应用 | ELISA |
| 定量/定性 | 定量检测 |
| 检测范围 | 12.5-800pg/mL |
| 灵敏度 | 6.25pg/mL |
| 精密度 | 板内，板间变异系数均<10% |
| 回收率 | 80%-120% |
| Swiss Prot | P53347 |
| Gene ID | 18413 |
| 研究领域 | 心血管 |
| 背景说明 | Oncostatin M (OSM) is a cytokine originally isolated from medium conditioned by PMA-treated U-937 human histiocytic leukemia cells based on its ability to inhibit growth of A375 melanoma cells. The human OSM cDNA encodes a 252 amino acid pre-pro-OSM polypeptide with a 25 residue hydrophobic signal peptide and a hydrophilic C-terminal domain that are proteolytically processed to generate the 196 residue mature form of OSM. Although both mature and pro-OSM are equally active in radio-receptor assays, the mature OSM is 5- to 60-fold more active in growth inhibition assays. Thus, proteolytic processing of the pro-OSM peptide may be important in regulating the in vivo activities of OSM. OSM initiates its biological activities by binding to specific cell surface receptors. The gp130, a signal transducing component (beta subunit) of the IL-6, LIF and CNTF receptor complexes, was identified as a low-affinity OSM receptor that does not transduce OSM signals. The low affinity LIF receptor (LIF R, a gp130-related protein) has now been identified to be a component of a high-affinity OSM receptor that will transduce OSM signals. Since OSM is also active on cells that do not express LIF R, a specific OSM receptor that does not involve LIF R must also exist. Besides its growth inhibitory activities on human A375 melanoma and mouse M1 myeloid leukemic cells, as well as on other solid tumor cells, OSM also has growth stimulatory activities on normal fibroblasts, AIDS-Kaposis sarcoma cells, and a human erythroleukemia cell line, TF-1. Other OSM-mediated activities reported to date include: stimulation of plasminogen activator activity in cultured bovine aortic endothelial cells, regulation of IL-6 expression in human endothelial cells, and stimulation of LDL uptake and up-regulation of cell surface LDL receptors in HepG2 cells. |
| 单位 | 盒 |
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