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- 2025年07月30日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃，2 years.(Avoid freeze/thaw cycles)
- 保质期：
Store at -20℃，2 years.(Avoid freeze/thaw cycles)
- 英文名：
Biotin-Neurokinin B
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 规格：
10mg/5mg/1mg
| 规格： | 10mg | 产品价格： | ￥3470.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥2480.0 |
| 规格： | 1mg | 产品价格： | ￥990.0 |
| 基本信息 | |
| 产品类型 | 多肽 |
| CAS | No.141801-26-5 |
| 单字母序列 | YPFF-NH2 |
| 三字母序列 | Tyr-Pro-Phe-Phe-NH2 |
| 别名 | 内MOP肽 2;EndoMor-phin-2 |
| 分子式 | C32H37N5O5 |
| 分子量 | 571.68 |
| 纯度 | ≥95% |
| 外观(性状) | 冻干粉;Lyophilized powder |
| 盐体系 | TFA盐;Trifluoroacetate salt |
| 来源 | 合成;Synthetic |
| 储存条件 | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 类别/标签 | opium肽(opioid peptides) |
| 规格 | EndoMor-phin 2，一种高度选择性的高亲和力μ-opioid受体激动剂 ， 对kappa3结合位点具有高亲和力 ，Ki为 20 到 30 nM 之间。EndoMor-phin 2, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM. |
| In Vitro | EndoMor-phin 2 is an endogenous opioid peptide and one of the two EndoMor-phins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with EndoMor-phin 1 (EM-2). The two EndoMor-phins display reasonable affinities for kappa3 binding sites, with Ki values between 20 and 30 nM. EndoMor-phin 1 and EndoMor-phin 2 compete both μ1 and μ2 receptor sites quite potently. EndoMor-phins have little appreciable affinity for either delta or kappa1 binding sites, with Ki values greater than 500 nM. |
| In Vivo | Both EndoMor-phin 1 and EndoMor-phin 2 are potent analgesics with peak effects seen at 10 and 15 min, respectively. All subsequent studies are performed at peak effect. Both compounds are fully active supraspinally and spinally, with no indication of ceiling effects. EndoMor-phin 1 is significantly more potent spinally than supraspinally and, at the spinal level, it is significantly more potent than EndoMor-phin 2. The response of both agents are readily reversed by nalo-xone. β-FNA, a highly selective μ antagonist, effectively reverses the actions of both EndoMor-phins. Neither compound have analgesic activity in CXBK mice at a dose which produced over 70% analgesia in control CD-1 mice. |
| 单位 | 瓶 |
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文献和实验Bull，2020, 36(3):199‒201] 图 3 AAV1 顺向跨突触标记 [J Neurosci，2020，Apr 15;40(16):3250-3267] 图 4 rAAV2-retro 逆行非跨突触标记 [Neuron, 2016, 92(2):372-382] 可跨血脑屏障的 AAV 血清型⸺AAV-PHP.S、AAV-PHP.B、AAV-PHP.eB、PG008、AAV9P801、VCAP-101、VCAP-102 血脑屏障（BBB）的存在对中枢神经系统（CNS
Acrine Orange 吖啶橙 ARs arsanilic acid 对氨苯砷酸 α-1-AT alpha(α)-1-anti-trypsin α-1-抗胰蛋白酶 BCDF B cell differetiation factor B细胞分化因子 BCGF B cell growth protein B细胞生长因子 BGP bone growth protein 骨生长蛋白 BGP brain-gut peptides 脑肠肽 BMP
位点的序列，包括肽库和肽芯片 [5，6] 的多种技术可用来鉴定激酶底物。此外，一种 λ 噬菌体 cDNA 表达文库的固相磷酸化筛选 [ 7，8 」以及不同蛋白质相互作用筛选方法，如覆盖方法 [ 9，11] 和酵母双杂交系统 [ 12，14] 已被应用在这方面。最近，蛋白激酶被改造成可接受人工合成的腺苷三磷酸盐（环戊基 ATP ) 模拟物，并用于鉴定特异底物。初步的研究已经证明，通过激酶来研究磷酸化的蛋白质芯片是可行的 [ 18，19] 。为了确定磷酸化位点，抗磷酸化蛋白表位 [6] 的抗体将用于蛋白
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